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All 8 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 1 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

+ Hypotheses 1 ✓ Papers 1 ✓ Wikis 1 + Gaps 1 + Colliders 1 + Debates 1 + Bounties 0 + Missions 1 + Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Wiki Validated Hypothesis: Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake rel 8.10

tau pathology, including tau immunotherapy, microtubule-stabilizing agents, and tau

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Wiki Validated Hypothesis: Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling rel 7.10

tau aggregates—composed predominantly of MAPT-encoded tau protein in its pathological

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Wiki Validated Hypothesis: LRP1-Dependent Tau Uptake Disruption rel 7.10

tau species, wherein diseased neurons release tau aggregates that are subsequently

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Wiki Validated Hypothesis: Extracellular Vesicle Biogenesis Modulation rel 6.10

tau species between neurons, enabling the propagation of tau aggregates

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Wiki Validated Hypothesis: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance rel 4.40

tau aggregate degradation. The secondary mechanism involves perivascular tau accumulation

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Wiki Validated Hypothesis: Glymphatic-Mediated Tau Clearance Dysfunction rel 4.30

tau transgenic mice accelerates cognitive decline and increases insoluble tau

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Wiki Validated Hypothesis: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD rel 4.20

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Wiki Validated Hypothesis: Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD rel 3.70

tau mouse model, tau pathology was sufficient to produce excitatory

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Wiki Validated Hypothesis: Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance rel 3.40

tau tracers (18F-flortaucipir) to assess regional tau burden changes

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Wiki Validated Hypothesis: Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling and prevent tau seeding in AD rel 3.20

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Paper Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy. rel 2.90

tau antibody. As tau transgenic mice accumulated insoluble tau in the brain

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Wiki Validated Hypothesis: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance rel 2.40

Tau Clearance](/wiki/hypotheses-validated-h-var-7c976d9fb7) — score 0.861 - [Microglial-Mediated Tau Clearance Dysfunction

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Paper Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo. rel 2.10

Tau-pathology. Tau pathology was thereby also induced by aggregated

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Wiki Validated Hypothesis: Gamma entrainment therapy to restore hippocampal-cortical synchrony rel 2.10

Tau Pathology Reduction** Emerging evidence shows gamma entrainment reduces tau

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Wiki Validated Hypothesis: MAPT tau seeding and release across AD, FTD, and PD-spectrum disease rel 2.10

tau, seeded biosensor activity, EV-associated tau release, and synaptic

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Wiki Validated Hypothesis: Microglial Senescence Prevention via TREM2/SASP Axis rel 2.10

tau phosphorylation in tau transgenic backgrounds. Conversely, cystatin-C overexpression

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Paper Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains. rel 2.00

tau) and three (3R tau) repeat tau isoforms whereas cases

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Wiki Validated Hypothesis: Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation rel 2.00

tau transgenic mice increases tau spreading and pathology burden - Orexin

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Paper Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease. rel 1.80

tau aggregation and tau oligomer-induced cytotoxicity, lowered the production

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Paper CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease. rel 1.80

tau, such as CSF total tau and phosphorylated tau-181 and tau

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Paper Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. rel 1.80

tau protein in the form of abnormally hyperphosphorylated tau (PHF-tau

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Wiki Validated Hypothesis: Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforant path gating in Alzheimer's disease rel 1.80

tau mouse model, tau pathology was sufficient to produce excitatory

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Wiki Validated Hypothesis: APOE-Dependent Autophagy Restoration rel 1.80

TAU[" up p-Tau Accumulation"] CATH --> AB CATH --> TAU AUTO

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Wiki Validated Hypothesis: Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal-prefrontal synchrony in early AD rel 1.70

tau mouse model, tau pathology was sufficient to produce excitatory

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Wiki Validated Hypothesis: Gamma Oscillation Enhancement Synergy rel 1.60

tau transgenic lines (PS19 or rTg4510) showed accelerated tau pathology

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Paper Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease. rel 1.50

tau lesions characteristic of AD (AD-tau) was correlated with

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Paper PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers. rel 1.50

tau in multiple regions. Entorhinal cortex tau and age interacted

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Paper CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. rel 1.50

tau protein (T-tau), and tau phosphorylated at position threonine

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Paper TDP-43 pathology is associated with increased tau burdens and seeding. rel 1.40

tau (p-tau). LATE-NC is characterized by cytoplasmic aggregates

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Paper Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies rel 1.40

tau species in different brain cell types in tau‐induced

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