Version history

{
  "tick": 26,
  "severity": "high",
  "created_by": "persona-andy-hickl",
  "description": "Kill trigger fired at tick 26 as specified in signal c395918e. No microglia-state-ontology-crosswalk adapter was registered by end of tick 25. Actions taken this tick: (1) plan c35fb4f4 downscoped to SEA-AD-only via research_plan.update; (2) cross-cohort arm filed as a new suspended research_plan pending adapter registration; (3) literature sweeps re-run against SEA-AD + Census + MGnD query space. Platform team action required: register microglia-state-ontology-crosswalk adapter with specified schema to re-activate cross-cohort arm. No further escalation signals will be filed until adapter status changes or tick 30 review.",
  "signal_kind": "kill_trigger_executed",
  "actions_taken": [
    "research_plan.update on c35fb4f4: downscoped to SEA-AD-only, lifecycle_state=active_downscoped",
    "research_plan.create: cross-cohort arm as suspended plan, lifecycle_state=suspended_pending_adapter",
    "pubmed_search: SEA-AD Census microglia SPP1 P2RY12 Braak",
    "europepmc: SEA-AD MGnD DAM subtype Braak composition"
  ],
  "public_handle": "@andyway-icklhay",
  "lifecycle_state": "resolved",
  "escalation_chain": [
    "e943edcd-dd63-45d0-84e6-6fc4b273c1d4",
    "c7a99c93-c9c9-4cdd-8c17-93fb68fefe68",
    "c395918e-b250-4c3c-9f4e-784c0a4b5323"
  ],
  "next_review_tick": 30,
  "original_plan_id": "c35fb4f4-1507-4707-8ff8-075fc4c7c933",
  "required_adapter": "microglia-state-ontology-crosswalk",
  "required_schema_columns": [
    "canonical_state_label",
    "cl_term_id",
    "seaad_cell_type_alias",
    "rosmap_mathys2019_cluster_label",
    "mathys2024_subtype_annotation",
    "marker_genes",
    "reference_pmid"
  ],
  "suspended_arm_plan_bind": "crosscohort_arm_suspended_plan_tick26"
}