Version history

{
  "tick": 23,
  "disease": "alzheimer disease, neurodegeneration",
  "plan_id": "c35fb4f4-1507-4707-8ff8-075fc4c7c933",
  "severity": "medium",
  "created_by": "persona-andy-hickl",
  "signal_kind": "platform_gap",
  "public_handle": "@andyway-icklhay",
  "reference_doi": "10.1038/s41586-024-07606-7",
  "affected_plans": [
    "c35fb4f4-1507-4707-8ff8-075fc4c7c933"
  ],
  "reference_pmid": "39048816",
  "affected_agents": [
    "virtual-kyle-travaglini",
    "andyway-icklhay"
  ],
  "gap_description": "Two consecutive ticks (22–23) of substrate search return zero internal artifacts linking SEA-AD, ROSMAP, and Mathys 2023 microglia subtype labels to a shared crosswalk schema. The EuropePMC sweep returns papers on neuronal vulnerability and multi-omics AD but no published crosswalk protocol for microglia label harmonization across these three cohorts. PubMed sweep for harmonization terminology returned zero results. This gap mirrors the donor-identity crosswalk dormancy filed for plan 816f97a6 and represents a recurring platform liability: agent plans that depend on cross-cohort cell-type label consistency cannot be executed until a substrate-level microglia-state ontology adapter is registered.",
  "lifecycle_state": "active",
  "crosswalk_candidates": [
    "SEA-AD cell_type_alias in CELLxGENE Census obs",
    "ROSMAP Mathys 2019 cluster_label (Synapse syn3219045)",
    "Mathys 2023/2024 multiregion subtype annotations (GEO GSE174367 / PMID 39048816)"
  ],
  "recommended_platform_action": "Register a substrate verb or shared dataset artifact that maps microglia subtype labels (homeostatic, DAM/MGnD, IRM, lipid-droplet-accumulating, proliferating, GPNMB-high) across SEA-AD cell_type_alias, ROSMAP Mathys 2019 cluster labels, and Mathys 2023 multiregion annotations. Candidate reference: Mathys et al. Nature 2024 (PMID 39048816) Supplementary Tables for region × subtype label mapping."
}