Version history

{
  "kind": "infographic",
  "prompt": "Psilocybin clinical trial data for substance use disorders",
  "provider": "other",
  "raw_fields": {
    "title": "Psilocybin clinical trial data for substance use disorders",
    "papers": [
      {
        "n": 17,
        "doi": "10.1001/jamanetworkopen.2026.0972",
        "value": "significantly increased long-term abstinence vs nicotine patch",
        "cite_key": "Johnson2026",
        "condition": "Psilocybin vs nicotine patch for smoking cessation",
        "scope_region": "systemic/serotonergic",
        "scope_population": "treatment-seeking smokers",
        "value_source_sentence": "significantly increased long-term abstinence compared with nicotine patch"
      },
      {
        "n": null,
        "doi": "10.1176/appi.ajp.20230887",
        "value": "multidimensional personality changes following psilocybin therapy",
        "cite_key": "Pagni2025",
        "condition": "Psilocybin for AUD - personality assessment",
        "scope_region": "central serotonergic",
        "scope_population": "AUD patients",
        "value_source_sentence": "Multidimensional Personality Changes Following Psilocybin-Assisted Therapy in Patients With Alcohol Use Disorder"
      },
      {
        "n": 1068,
        "doi": "10.1016/j.pnpbp.2025.111541",
        "value": "adverse event profile manageable in controlled settings",
        "cite_key": "Bukovsky2025",
        "condition": "Psilocybin safety across clinical trials",
        "scope_region": "systemic",
        "scope_population": "clinical trial participants",
        "value_source_sentence": "safety profile and the management of potential adverse events across 1068 participants"
      }
    ],
    "figure_id": "fig_sec11_psilocybin_trials",
    "comparison": "Psilocybin trial outcomes for alcohol and tobacco cessation",
    "figure_type": "study_summary_table",
    "n_definition": "Participants enrolled and completing study protocols",
    "source_cluster": 10,
    "taxonomic_level": "N/A",
    "homogeneity_check": "Studies represent different phases of psilocybin research (pilot vs. safety aggregation). Small sample sizes in efficacy trials (n=17) compared to safety data (n=1068). Blinding adequacy varies. Different target conditions (tobacco vs alcohol) limit direct comparison."
  },
  "section_id": "section_12_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
  "target_ref": "wiki_page:computationalreviewaddiction-12",
  "review_repo": "ComputationalReviewAddiction",
  "section_ref": "wiki_page:computationalreviewaddiction-12",
  "source_path": "evidence/section_12_evidence.json",
  "source_refs": [
    "paper:paper-2d380f74b24d",
    "paper:paper-a8f1599384b3",
    "paper:paper-e2c72ec1f4a3"
  ],
  "section_title": "Synthesis: An Evidence Scorecard for Addiction Neuroscience",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d95cfb705572",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}