Differential Control of Spike Timing by SST vs PV Interneurons

{
  "papers": [
    {
      "doi": "10.1038/nn.3077",
      "value": "SST silencing → increased burst firing, no theta phase change; PV silencing → theta phase shift to trough, no burst change",
      "method": "optogenetics + in vivo electrophysiology",
      "metric": "Effect of SST vs PV silencing on place cell firing",
      "cite_key": "Royer2012",
      "condition": "hippocampus, head-fixed mouse on treadmill",
      "study_system": "mouse",
      "value_source_sentence": "SOM interneuron silencing powerfully increased burst firing without altering the theta phase of spikes. PV interneuron silencing had no effect on burst firing, but instead shifted the spikes' theta phase toward the trough of theta"
    },
    {
      "doi": "10.1038/nature12176",
      "value": "PV: millisecond synchrony, fast powerful inhibition; SOM: weak variable inhibition on firing output",
      "method": "optogenetic tagging + in vivo electrophysiology",
      "metric": "PV vs SOM inhibitory impact dynamics",
      "cite_key": "Kvitsiani2013",
      "condition": "anterior cingulate cortex, reward foraging",
      "study_system": "mouse",
      "value_source_sentence": "Pv neurons could fire in millisecond synchrony exerting fast and powerful inhibition on principal cell firing, while the inhibitory impact of Som neurons on firing output was weak and more variable"
    },
    {
      "doi": "10.7554/elife.09868",
      "value": "PV: non-specific inhibition (equal frequent/rare); SST: selective reduction of frequent-stimulus responses",
      "method": "optogenetics + auditory cortex electrophysiology",
      "metric": "SST vs PV control of stimulus adaptation",
      "cite_key": "Natan2015",
      "condition": "awake mouse, auditory stimulus-specific adaptation",
      "study_system": "mouse",
      "value_source_sentence": "suppression of PVs led to an equal increase in responses to frequent and rare tones. suppression of SOMs led to an increase in responses to frequent, but not to rare tones"
    },
    {
      "doi": "10.1016/j.neuron.2017.02.017",
      "value": "Feedback dendritic inhibition attenuates EC input at place field entry; depression of proximal inhibition allows CA3 input at exit",
      "method": "high-density in vivo electrophysiology",
      "metric": "Distal dendritic inhibition control of spike timing within theta",
      "cite_key": "FernandezRuiz2017",
      "condition": "hippocampus CA1, multiple tasks",
      "study_system": "rat",
      "value_source_sentence": "Feedback potentiation of distal dendritic inhibition by CA1 place cells attenuated the excitatory entorhinal input at place field entry"
    }
  ],
  "comparison_id": "sst-pv-spike-timing-control",
  "comparison_name": "Differential Control of Spike Timing by SST vs PV Interneurons",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "How SST and PV interneurons exert complementary but distinct control over pyramidal neuron spike timing, burst firing, and theta phase. This comparison is critical for understanding the temporal coordination function of SST neurons.",
  "homogeneity_check": {
    "caveats": [
      "Brain regions differ (hippocampus, ACC, auditory cortex)",
      "Behavioral tasks differ",
      "Species mostly mouse except one rat study",
      "All convergent on SST-PV differential but measurements are qualitatively different"
    ],
    "comparable": false
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-257e18af2151",
  "paper:paper-7eea29f8098d",
  "paper:paper-9e69c159c046",
  "paper:paper-f8c7cbda4ea7"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}