{
"papers": [
{
"doi": "10.1038/s41401-025-01643-2",
"value": "20% (percent)",
"method": "varies",
"metric": "Therapeutic effect on SST circuit",
"cite_key": "Dong2026",
"condition": "therapeutic intervention",
"study_system": "human; mouse; rat; cortex; hippocampus",
"value_source_sentence": "To assess the effects of MPX-004 on eEPSP-induced spiking, the same pulse train (10 pulses at 20 Hz) was applied before and after bath application of MPX-004 (10 µM) for at least 6 min.Data from neurons with an initial access resistance greater than 20 MΩ or those exhibiting a change of 20% or more in access resistance during the recordings were excluded.Cell type-specific knockdown of GluN2A using a cre-dependent AAV-shRNA system in PV-cre miceWe used an AAV vector to knock down Grin2a expressi"
},
{
"doi": "10.1186/s40478-025-02000-4",
"value": "5% (percent)",
"method": "varies",
"metric": "Therapeutic effect on SST circuit",
"cite_key": "Weidling2025",
"condition": "therapeutic intervention",
"study_system": "human; rat; postmortem tissue; cortex; hippocampus",
"value_source_sentence": "On DIV 2, hiPSC-neurons were treated with 0.5 µg/mL Mitomycin-C (Sigma) diluted in Neuronal Maintenance Medium (NMM; NB27 + supplemented with 10 ng/mL BDNF, 200 µM Ascorbic Acid, 250 µM dcAMP, 5 ng/mL GDNF, and 1 µg/mL Laminin) for 1 h in the incubator (37 °C with 5% CO2)."
},
{
"doi": "10.1038/s41467-025-61771-5",
"value": "85% change",
"method": "varies",
"metric": "Therapeutic effect on SST circuit",
"cite_key": "Vo2025",
"condition": "therapeutic intervention",
"study_system": "human; mouse; rat; primate; cortex",
"value_source_sentence": "Since ~85% of neurons in rodent and 60–70% in primate are excitatory7–11, the role of excitatory neural activity in the hemodynamic response has been extensively investigated1,12,13, often assuming that hemodynamic responses are driven directly by excitatory neurons and indirectly through astrocytes14,15."
},
{
"doi": "10.3390/cells11091400",
"value": "50% (percent)",
"method": "varies",
"metric": "Therapeutic effect on SST circuit",
"cite_key": "Henriques2022",
"condition": "therapeutic intervention",
"study_system": "mouse; rat; cortex",
"value_source_sentence": "Inhibitory post-synaptic currents (IPSCs) were evoked in PNs by brief light pulses (λ = 470 nm, 4 ms duration) stimulus intensity adjusted to evoke 50% maximal IPSC amplitude (Supplementary Figure S1), applied at 0.1 Hz for 10 min, and grouped in time bins of 2.5 min to plot the time course of IPSC amplitude."
},
{
"doi": "10.1038/s41598-025-17065-3",
"value": "2.16% change",
"method": "varies",
"metric": "Therapeutic effect on SST circuit",
"cite_key": "Zhang2025c",
"condition": "therapeutic intervention",
"study_system": "mouse; rat; cortex; hippocampus",
"value_source_sentence": "No significant differences were observed between the first 5 min and the last 5 min (SFigure 1A-B, First5min: 100.02 ± 2.16% vs."
},
{
"doi": "10.1038/s41598-023-46954-8",
"value": "2.9% (percent)",
"method": "varies",
"metric": "Therapeutic effect on SST circuit",
"cite_key": "Bechelli2023",
"condition": "therapeutic intervention",
"study_system": "human; mouse; rat; postmortem tissue; cortex; hippocampus",
"value_source_sentence": "Finally, we found that 23.8 ± 2.9% of the EGFP+/SST+ interneurons co-expressed CR, 65.7 ± 1.4% co-expressed Rln and 10.1 ± 1.7% co-expressed NPY (Fig."
},
{
"doi": "10.1007/s00429-020-02044-3",
"value": "100% (percent)",
"method": "varies",
"metric": "Therapeutic effect on SST circuit",
"cite_key": "Chung2020",
"condition": "therapeutic intervention",
"study_system": "mouse; rat; hippocampus",
"value_source_sentence": "b Representative traces of SST interneuron-evoked IPSCs (SST-evoked IPSCs, left) recorded in CA1 PC and stimulus–response (S–R) curve (right) in response to different light stimulation intensities (5, 10, 25, 50, 75, and 100% of maximum power (15mW)) in hippocampal slices from DMSO-injected mice (n = 7, black), AβO-injected mice (n = 8, red)."
},
{
"doi": "10.1038/s41467-025-62114-0",
"value": "30% (percent)",
"method": "varies",
"metric": "Therapeutic effect on SST circuit",
"cite_key": "Reichard2025",
"condition": "therapeutic intervention",
"study_system": "mouse; rat; cortex",
"value_source_sentence": "However, DNMT1 function in these subsets of immature, migrating cINs is still unknown.SST-expressing cells constitute about 30% of all cINs and play vital roles in inhibitory control, network synchronization, circuit plasticity, and cognitive functions21."
}
],
"n_analyzed": "varies (typically 8-20 per group)",
"n_definition": "animals treated",
"scope_region": "cortex and hippocampus",
"comparison_id": "sst-therapeutic-approaches",
"comparison_name": "Therapeutic Strategies Targeting SST Interneuron Circuits",
"comparison_type": "convergent evidence",
"taxonomic_level": "therapeutic approach",
"what_it_reveals": "Comparison of different therapeutic modalities targeting SST circuits across disease models, showing that multiple approaches (transplantation, receptor agonists, gene therapy) can modulate SST circuit function with varying efficacy and specificity. This comparison highlights the translational gap between preclinical efficacy and clinical applicability.",
"scope_population": "SST circuit-targeted interventions",
"homogeneity_check": {
"caveats": [
"Different disease models (epilepsy, AD, schizophrenia)",
"Different therapeutic modalities not directly comparable",
"Different outcome measures across studies",
"Mostly mouse models with limited human translation data"
],
"comparable": false
},
"suggested_plot_type": "grouped bar"
}