Version history

{
  "kind": "infographic",
  "prompt": "The nature of SST-mediated inhibition (divisive vs subtractive) is contested and appears to depend on experimental conditions, challenging the simple classification of SST as subtractive inhibitors.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1038/nature11347",
        "value": "Subtractive (offset change)",
        "method": "in vivo optogenetics and electrophysiology",
        "metric": "Type of inhibition by SST activation",
        "cite_key": "Wilson2012",
        "condition": "SST activation alone",
        "study_system": "mouse V1",
        "value_source_sentence": "dendrite-targeting, somatostatin-expressing (SOM) neurons primarily change response offset"
      },
      {
        "doi": "10.3389/fncir.2019.00040",
        "value": "Divisive (gain change)",
        "method": "in vivo optogenetics",
        "metric": "Type of inhibition by simultaneous SST+PV activation",
        "cite_key": "Ingram2019",
        "condition": "SST + PV simultaneous activation",
        "study_system": "mouse V1",
        "value_source_sentence": "Divisive Inhibition Prevails During Simultaneous Optogenetic Activation of PV and SST interneurons"
      },
      {
        "doi": "10.1152/jn.00732.2015",
        "value": "Context-dependent (both possible)",
        "method": "recurrent network modeling",
        "metric": "Model prediction for SST inhibition type",
        "cite_key": "LitwinKumar2016",
        "condition": "varies with connectivity and tuning",
        "study_system": "computational model",
        "value_source_sentence": "study the roles of each interneuron subtype in disinhibition, surround suppression, and subtractive or divisive modulation of orientation tuning curves"
      },
      {
        "doi": "10.7554/elife.99808",
        "value": "Decoupled (multiple classes resolve trade-off)",
        "method": "analytical and simulation",
        "metric": "Stability-gain trade-off with multiple IN classes",
        "cite_key": "Bos2025",
        "condition": "multiple interneuron classes",
        "study_system": "computational model",
        "value_source_sentence": "In cortical models with a single inhibitory neuron class, network stabilization and gain control work in opposition to one another"
      }
    ],
    "comparison_id": "gain-control-type-across-studies",
    "comparison_name": "Divisive vs Subtractive Inhibition by SST Interneurons Across Studies",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "The nature of SST-mediated inhibition (divisive vs subtractive) is contested and appears to depend on experimental conditions, challenging the simple classification of SST as subtractive inhibitors.",
    "homogeneity_check": {
      "caveats": [
        "Mix of experimental and computational studies",
        "Different SST activation protocols",
        "Different metrics for divisive vs subtractive"
      ],
      "comparable": false
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_07_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-07",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-07",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-00de1a2c593e",
    "paper:paper-0539949fe271",
    "paper:paper-8f25714ab7fe",
    "paper:paper-cf0d183b1c6d"
  ],
  "section_title": "Circuit Motifs and Dendritic Computation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_07_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}