Astrocyte Calcium Signaling figure 1

{
  "papers": [
    {
      "doi": "10.1038/nn.4001",
      "note": "Srinivasan 2015: somatic Ca2+ essentially absent but process Ca2+ preserved in IP3R2-/-",
      "value": "soma: essentially absent; processes: preserved",
      "compartment": "soma (primary); fine processes (secondary)",
      "measurements": [
        {
          "value": "largely abolished (qualitative)",
          "compartment": "soma",
          "value_source_sentence": "In the case of WT mouse astrocytes expressing GCaMP6f, we could readily identify somatic Ca 2+ fluctuations, whereas these were essentially absent in IP3R2 − / − astrocytes."
        },
        {
          "value": "preserved (qualitative)",
          "compartment": "fine processes",
          "value_source_sentence": "Rather, we found a rich variety of previously unknown IP3R2 independent Ca 2+ fluctuations within astrocyte processes that responded to pharmacological and sensory stimuli in brain slices and in vivo , respectively."
        }
      ],
      "value_source_sentence": "In the case of WT mouse astrocytes expressing GCaMP6f, we could readily identify somatic Ca 2+ fluctuations, whereas these were essentially absent in IP3R2 − / − astrocytes."
    },
    {
      "doi": "10.3389/fnbeh.2014.00384",
      "note": "Petravicz 2014: IP3R2-KO has normal behavior",
      "value": "behavioral tasks normal",
      "compartment": "whole-cell / behavior",
      "value_source_sentence": "We present the novel finding that behavioral processes are unaffected by lack of astrocyte IP3R-mediated Ca(2+) signals."
    },
    {
      "doi": "10.1523/jneurosci.5289-11.2011",
      "note": "Takata 2011: NBM-whisker plasticity lost in IP3R2-/-",
      "value": "plasticity abolished",
      "compartment": "somatic (cholinergic plasticity)",
      "value_source_sentence": "The elevation of astrocytic [Ca(2+)](i) is crucial in this type of synaptic plasticity, as the plasticity could not be induced in inositol-1,4,5-trisphosphate receptor type 2 knock-out (IP(3)R2-KO) mice, in which astrocytic [Ca(2+)](i) surges are diminished."
    },
    {
      "doi": "10.3390/cells14141103",
      "note": "Ye et al 2025: confirms ongoing controversy re IP3R2 phenotype",
      "value": "locomotion-evoked process Ca2+ reduced",
      "compartment": "process/sensory-evoked",
      "value_source_sentence": "We report that vS1 astrocytic Ca<sup>2+</sup> elevation in both wild-type and <i>Itpr2</i><sup>-/-</sup> mice was significantly modulated by free whisking and locomotion."
    }
  ],
  "axis_label": "Fraction of astrocyte Ca2+ activity remaining in Itpr2-/- (%)",
  "comparison_topic": "Effect of Itpr2 (IP3R2) genetic deletion on astrocyte Ca2+ signals, broken down by subcellular compartment"
}

[
  "paper:paper-29a722660e41",
  "paper:paper-5e6adeb1c300",
  "paper:paper-9c595c660d61",
  "paper:paper-883c8368100c"
]

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "1a55da0634a3bc04e5688792ed12141ce271d28e",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes"
}