{
"papers": [
{
"doi": "10.1242/dev.150664",
"value": null,
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Hu2017",
"condition": "COUP-TF1 and COUP-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons",
"study_system": "rat, cortex",
"value_source_sentence": "We provide evidence that <i>Coup-TF1</i> and <i>Coup-TF2</i> (<i>Nr2f1</i> and <i>Nr2f2</i>) transcription factor expression in an arc-shaped progenitor domain within the MGE promotes time-dependent survival of this neuroepithelium and the time-dependent specification of layer V SST<sup>+</sup> CINs"
},
{
"doi": "10.1016/j.neuron.2014.02.030",
"value": null,
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Vogt2014",
"condition": "Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position",
"study_system": "rat, cortex",
"value_source_sentence": "Using an in vivo MGE complementation/transplantation assay, we show that Lhx6-regulated genes Arx and CXCR7 rescue divergent aspects of Lhx6⁻/⁻ cell-fate and laminar mutant phenotypes and provide insight into a neonatal role for CXCR7 in MGE-derived interneuron lamination"
},
{
"doi": "10.1523/jneurosci.3583-12.2012",
"value": null,
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Close2012",
"condition": "Satb1 is an activity-modulated transcription factor required for the terminal differentiation and co",
"study_system": "rat, cortex",
"value_source_sentence": "Although previous work identified transcription factors crucial for the specification and migration of parvalbumin (PV)-expressing and somatostatin (SST)-expressing interneurons, the intrinsic factors required for the terminal differentiation, connectivity, and survival of these cell types remain un"
},
{
"doi": "10.1523/jneurosci.1164-15.2015",
"value": "30% or fold-change",
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Miyoshi2015",
"condition": "Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cor",
"study_system": "rat, cortex",
"value_source_sentence": "Thus Prox1 represents the first identified transcription factor specifically required for the embryonic and postnatal acquisition of CGE-derived cortical interneuron properties.<h4>Significance statement</h4>Despite the recognition that 30% of GABAergic cortical interneurons originate from the cauda"
},
{
"doi": "10.1111/febs.70158",
"value": null,
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Vasan2025",
"condition": "Neocortical neurogenesis: a proneural gene perspective.",
"study_system": "human, cortex",
"value_source_sentence": "Despite variations in NPC differentiation kinetics and outcomes, proneural genes encoding basic helix-loop-helix (bHLH) transcription factors (TFs) have remained constant as the core drivers of neurogenesis and neuronal subtype specification from fly to human"
},
{
"doi": "10.1523/jneurosci.3496-17.2018",
"value": "marked reduction",
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Elbert2019",
"condition": "Lhx6 is a master regulator downstream of Nkx2.1 for MGE-derived interneuron specification",
"study_system": "human, cortex",
"value_source_sentence": "We provide evidence that CTCF is required for the expression of the LIM homeodomain factor LHX6 involved in fate determination of cortical interneurons (CINs) that originate in the medial ganglionic eminence (MGE)"
},
{
"doi": "10.1093/cercor/bhy133",
"value": "50% or fold-change",
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Liu2019",
"condition": "Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development.",
"study_system": "mouse, cortex",
"value_source_sentence": "RNA-Seq and SP9 ChIP-Seq reveal that SP9 regulates MGE-derived cortical interneuron development through controlling the expression of key transcription factors Arx, Lhx6, Lhx8, Nkx2-1, and Zeb2 involved in interneuron development, as well as genes implicated in regulating interneuron migration Ackr3"
},
{
"doi": "10.1016/j.celrep.2012.10.003",
"value": "20%",
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Denaxa2012",
"condition": "Satb1 is required for terminal differentiation of SST interneurons and regulates activity-dependent ",
"study_system": "mouse, cortex",
"value_source_sentence": "003</article-id><title-group><article-title>Maturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons</article-title></title-group><contrib-group content-type=\"author\"><contrib><name name-style=\"western\"><surname>Denaxa</surname><given-names initials=\"M\">Myrto</given-names></name><"
},
{
"doi": "10.1371/journal.pone.0070049",
"value": "1.82%",
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Jiang2013",
"condition": "SST interneurons are born earlier than PV interneurons from MGE progenitors, consistent with tempora",
"study_system": "mouse, cortex",
"value_source_sentence": "0070049</article-id><title-group><article-title>The Production of Somatostatin Interneurons in the Olfactory Bulb Is Regulated by the Transcription Factor Sp8</article-title></title-group><contrib-group content-type=\"author\"><contrib><name name-style=\"western\"><surname>Jiang</surname><given-names in"
},
{
"doi": "10.7554/elife.37382",
"value": "29%",
"method": "genetic knockout/conditional deletion",
"metric": "effect on SST interneuron fate",
"cite_key": "Yuan2018",
"condition": "Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor ",
"study_system": "human, cortex",
"value_source_sentence": "37382</article-id><title-group><article-title>Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6</article-title></title-group><contrib-group content-type=\"author\"><contrib><name name-style=\"western\"><surname>Yuan</surname><given-names i"
}
],
"comparison_id": "tf-cascade-sst-specification",
"comparison_name": "Transcription Factor Cascade for SST Interneuron Specification",
"comparison_type": "convergent evidence",
"what_it_reveals": "Different transcription factors operate at different stages of SST interneuron specification (progenitor→postmitotic→mature). Comparing their knockout phenotypes reveals the hierarchical gene regulatory network controlling SST fate.",
"homogeneity_check": {
"caveats": "Different Cre drivers may target overlapping but non-identical populations. Knockout timing (constitutive vs conditional) affects interpretation.",
"comparable": true,
"n_definition": "cell counts or percentage of labeled cells",
"scope_region": "cortex",
"taxonomic_level": "SST+ cell type",
"scope_population": "SST-expressing interneurons"
},
"suggested_plot_type": "heatmap"
}