Version history

{
  "kind": "infographic",
  "prompt": "The evidence for SST neurons mediating surround suppression has evolved from initial optogenetic demonstrations to more nuanced mechanistic understanding. This timeline shows how the original claim has been refined and complicated by subsequent studies.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1038/nature11526",
        "value": "SST neuron optogenetic activation enhanced surround suppression; inactivation reduced it",
        "method": "optogenetics + electrophysiology",
        "metric": "Surround suppression effect",
        "cite_key": "Adesnik2012",
        "condition": "awake mouse",
        "study_system": "mouse V1",
        "value_source_sentence": "A neural circuit for spatial summation in visual cortex."
      },
      {
        "doi": "10.1523/JNEUROSCI.5320-12.2013",
        "value": "Contrast-dependent differential contributions: SST contrast-invariant, PV contrast-dependent",
        "method": "optogenetics + electrophysiology",
        "metric": "PV vs SST contribution",
        "cite_key": "Nienborg2013",
        "condition": "awake mouse",
        "study_system": "mouse V1",
        "value_source_sentence": "Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing interneurons to surround suppression."
      },
      {
        "doi": "10.1523/JNEUROSCI.1735-19.2020",
        "value": "SST-mediated sustained suppression extends to auditory processing",
        "method": "optogenetics",
        "metric": "SST suppression in auditory cortex",
        "cite_key": "Lakunina2020",
        "condition": "awake mouse",
        "study_system": "mouse auditory cortex",
        "value_source_sentence": "Somatostatin-Expressing Interneurons in the Auditory Cortex Mediate Sustained Suppression."
      },
      {
        "doi": "10.1113/jp287265",
        "value": "Post-inhibitory rebounds confound interpretation; rebounds largest with visual stimulation",
        "method": "optogenetics + electrophysiology",
        "metric": "Optogenetic rebound artifacts",
        "cite_key": "Shapiro2025",
        "condition": "anesthetized mouse",
        "study_system": "mouse V1",
        "value_source_sentence": "We found converging evidence that rebounds were largest when interneuron photostimulation was coupled with visual stimuli that strongly activate V1."
      }
    ],
    "comparison_id": "sst-surround-suppression-evidence-timeline",
    "comparison_name": "Timeline of SST-Mediated Surround Suppression Evidence",
    "comparison_type": "timeline",
    "what_it_reveals": "The evidence for SST neurons mediating surround suppression has evolved from initial optogenetic demonstrations to more nuanced mechanistic understanding. This timeline shows how the original claim has been refined and complicated by subsequent studies.",
    "homogeneity_check": {
      "caveats": "Anesthetized vs awake preparations differ; all use SST-Cre (no subtype distinction); rebound study questions methodology of original findings",
      "n_definition": "Recording units and sessions vary",
      "scope_region": "V1 (3 studies) and auditory cortex (1 study)",
      "taxonomic_level": "SST class level (no subtype distinction)",
      "scope_population": "SST+ neurons (all subtypes lumped)"
    },
    "suggested_plot_type": "timeline"
  },
  "section_id": "section_13_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_13_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-13",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-13",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-03d61a0e26d7",
    "paper:paper-410b852f3cc3",
    "paper:paper-48f7973b62f1",
    "paper:paper-a98060d4d03f"
  ],
  "section_title": "Synthesis and Evidence Assessment",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_13_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}