Version history

{
  "kind": "infographic",
  "prompt": "PV interneuron tuning selectivity varies systematically across sensory cortical areas and species: broadly tuned in mouse V1, well-tuned in auditory cortex, and layer-dependent in primate V1. This suggests PV neurons pool local input nonselectively, with their apparent selectivity reflecting the local circuit architecture rather than intrinsic tuning mechanisms.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1038/nature11312",
        "value": "broadly tuned; PV activation sharpens nearby neuron tuning",
        "method": "multichannel extracellular recording + optogenetics",
        "metric": "PV+ orientation selectivity in visual cortex",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "recorded neurons",
        "scope_region": "visual cortex V1",
        "study_system": "mouse, V1, optogenetics + silicon probes",
        "taxonomic_level": "PV+ interneurons",
        "scope_population": "PV+ interneurons",
        "value_source_sentence": "elevated spiking of PV+ interneurons markedly sharpened orientation tuning and enhanced direction selectivity of nearby neurons",
        "experimental_conditions": "ChR2 activation of PV+ cells"
      },
      {
        "n": 0,
        "doi": "10.1523/JNEUROSCI.0663-13.2013",
        "value": "well-tuned for frequency; shallower gain than PV- neurons",
        "method": "extracellular recording + optogenetic tagging",
        "metric": "PV+ frequency selectivity in auditory cortex",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "recorded neurons",
        "scope_region": "auditory cortex",
        "study_system": "mouse, auditory cortex, optogenetic tagging",
        "taxonomic_level": "PV+ interneurons",
        "scope_population": "PV+ interneurons",
        "value_source_sentence": "auditory cortical PV+ neurons were well tuned for frequency, although very tightly tuned PV+ cells were uncommon",
        "experimental_conditions": "ChR2 optogenetic identification"
      },
      {
        "n": 0,
        "doi": "10.1093/cercor/bhx261",
        "value": "~10% of PV population mediates prominent effects; strong lateral inhibition",
        "method": "laminar recording + optogenetics",
        "metric": "PV+ spatiotemporal effects in somatosensory cortex",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "recorded neurons",
        "scope_region": "somatosensory barrel cortex",
        "study_system": "mouse, barrel cortex S1, optogenetics",
        "taxonomic_level": "PV+ interneurons",
        "scope_population": "PV+ interneurons",
        "value_source_sentence": "only a minor fraction (~10%) of the local PV population comprising no more than a few hundred neurons is optogenetically modulated, mediating the observed prominent and widespread effects",
        "experimental_conditions": "PV inhibition and activation"
      },
      {
        "n": 0,
        "doi": "10.21203/rs.3.rs-9117440/v1",
        "value": "gain control in granular layer; tuned suppression in extra-granular layers",
        "method": "laminar extracellular recording + optogenetics",
        "metric": "PV+ function in primate V1 across layers",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "recorded neurons",
        "scope_region": "visual cortex V1 (primate)",
        "study_system": "marmoset, V1, bidirectional optogenetics",
        "taxonomic_level": "PV+ interneurons",
        "scope_population": "PV+ interneurons",
        "value_source_sentence": "in the granular layer, PV+ cells implement divisive/multiplicative linear gain control, whereas in extra-granular layers they exert tuned nonlinear suppression that enhances orientation tuning",
        "experimental_conditions": "laminar optogenetic manipulation"
      }
    ],
    "comparison_id": "pv-tuning-selectivity-across-sensory-areas",
    "comparison_name": "PV Interneuron Tuning Selectivity Across Sensory Cortical Areas",
    "comparison_type": "cross-region comparison",
    "what_it_reveals": "PV interneuron tuning selectivity varies systematically across sensory cortical areas and species: broadly tuned in mouse V1, well-tuned in auditory cortex, and layer-dependent in primate V1. This suggests PV neurons pool local input nonselectively, with their apparent selectivity reflecting the local circuit architecture rather than intrinsic tuning mechanisms.",
    "homogeneity_check": {
      "caveats": [
        "Different sensory modalities (visual, auditory, somatosensory) with different stimulus feature spaces",
        "Mouse vs marmoset species comparison for visual cortex",
        "Different selectivity metrics across studies (orientation vs frequency vs spatial)"
      ],
      "n_definition_uniform": "true",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_08_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-08",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-08",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-7788d49563cb",
    "paper:paper-89a90cbbebc9",
    "paper:paper-97e6822b54d9",
    "paper:paper-f450ef113660"
  ],
  "section_title": "In Vivo Dynamics and Behavioural Correlates",
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
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  "generation_status": "complete",
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}