Distribution of Firing Patterns Among Biocytin-Filled Martinotti Cells

{
  "papers": [
    {
      "doi": "10.1113/jphysiol.2004.073353",
      "value": "90%",
      "method": "whole-cell patch-clamp + biocytin filling",
      "metric": "percentage with accommodating firing pattern",
      "cite_key": "Wang2004",
      "condition": "somatosensory cortex, P13-16, n=127",
      "study_system": "rat",
      "value_source_sentence": "MCs typically displayed spike train accommodation (90%; n = 127) in response to depolarizing somatic current injections."
    },
    {
      "doi": "10.1113/jphysiol.2004.073353",
      "value": "8%",
      "method": "whole-cell patch-clamp + biocytin filling",
      "metric": "percentage with non-accommodating firing pattern",
      "cite_key": "Wang2004",
      "condition": "somatosensory cortex, P13-16, n=127",
      "study_system": "rat",
      "value_source_sentence": "but some displayed non-accommodating (8%)"
    },
    {
      "doi": "10.1113/jphysiol.2004.073353",
      "value": "2%",
      "method": "whole-cell patch-clamp + biocytin filling",
      "metric": "percentage with irregular spiking",
      "cite_key": "Wang2004",
      "condition": "somatosensory cortex, P13-16, n=127",
      "study_system": "rat",
      "value_source_sentence": "and a few displayed irregular spiking responses (2%)"
    }
  ],
  "n_analyzed": "127",
  "n_definition": "individual recorded+filled neurons",
  "scope_region": "rat somatosensory cortex",
  "comparison_id": "mc-firing-pattern-distribution",
  "comparison_name": "Distribution of Firing Patterns Among Biocytin-Filled Martinotti Cells",
  "comparison_type": "convergent evidence",
  "taxonomic_level": "electrophysiological classification",
  "what_it_reveals": "Martinotti cells are electrophysiologically heterogeneous even when defined by strict morphological criteria. The 90/8/2% split (accommodating/non-accommodating/irregular) suggests a dominant but not exclusive firing phenotype.",
  "scope_population": "morphologically-defined Martinotti cells (biocytin-filled)",
  "homogeneity_check": {
    "caveats": [
      "Single study — independent replication of layer-specific firing pattern proportions needed",
      "Juvenile rat tissue (P13-16) — firing properties may differ in adult animals"
    ],
    "metric_consistent": true,
    "scope_region_uniform": true,
    "taxonomic_level_uniform": true,
    "scope_population_uniform": true
  },
  "suggested_plot_type": "grouped bar"
}

[
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]

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