Version history

{
  "kind": "infographic",
  "prompt": "TRN PV neurons serve dual roles in intrinsic excitability and circuit-level sensory gating",
  "provider": "other",
  "raw_fields": {
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      {
        "n": 0,
        "doi": "10.1523/jneurosci.1202-25.2026",
        "value": "increased burst, decreased tonic firing",
        "method": "patch-clamp, calcium imaging",
        "metric": "Burst vs tonic firing changes",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "PV neurons recorded",
        "scope_region": "thalamic reticular nucleus",
        "study_system": "Shank3-/- mouse TRN",
        "taxonomic_level": "broad category",
        "scope_population": "PV-expressing neurons",
        "value_source_sentence": "TRN PV neurons of Shank3-/- mice exhibit pronounced increases in burst firing occurrence, decreased tonic firing frequency, and faster dendritic calcium transient decay.",
        "experimental_conditions": "Shank3 knockout"
      },
      {
        "n": 0,
        "doi": "10.1007/s12264-025-01458-5",
        "value": "PV neurons modulate orientation selectivity",
        "method": "optogenetics, in vivo electrophysiology",
        "metric": "V1 orientation selectivity modulation",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "mice per condition",
        "scope_region": "thalamic reticular nucleus to V1",
        "study_system": "mouse TRN-dLGN-V1 circuit",
        "taxonomic_level": "broad category",
        "scope_population": "PV-expressing neurons",
        "value_source_sentence": "SOM-positive and PV-positive neurons in the TRN are powerful modulators of visual information encoding in V1.",
        "experimental_conditions": "optogenetic activation"
      }
    ],
    "comparison_id": "trn-pv-neuron-function",
    "comparison_name": "TRN PV neuron excitability and circuit function",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "TRN PV neurons serve dual roles in intrinsic excitability and circuit-level sensory gating",
    "homogeneity_check": {
      "caveats": [
        "Different experimental paradigms"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "true",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
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  "target_ref": "wiki_page:computationalreviewpv-09",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-09",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-1936bf669c0c",
    "paper:paper-7b2fd50083cd"
  ],
  "section_title": "Brain Region and Layer Context: Beyond Primary Sensory Cortex",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}