Version history

{
  "kind": "infographic",
  "prompt": "Anti-drug vaccine clinical and preclinical outcomes across target substances",
  "provider": "other",
  "raw_fields": {
    "title": "Anti-drug vaccine clinical and preclinical outcomes across target substances",
    "papers": [
      {
        "n": 266,
        "doi": "10.1080/21645515.2022.2140552",
        "value": "vaccinated groups 50 times more likely to be cocaine-free",
        "cite_key": "Scendoni2022",
        "condition": "Cocaine vaccine meta-analysis",
        "scope_region": "systemic (peripheral)",
        "scope_population": "cocaine-dependent patients",
        "value_source_sentence": "showed that vaccinated groups were 50 times more likely to cease cocaine"
      },
      {
        "n": 130,
        "doi": "10.3390/pharmaceutics14112368",
        "value": "IgA rather than IgG mediates protection",
        "cite_key": "Kosten2022",
        "condition": "Anti-cocaine vaccine antibody characterization",
        "scope_region": "systemic",
        "scope_population": "vaccinated subjects",
        "value_source_sentence": "Anti-Cocaine IgA Rather Than IgG Mediates Vaccine Protection from Cocaine Use"
      },
      {
        "n": null,
        "doi": "10.3390/brainsci15040364",
        "value": "reduced nicotine self-administration in rats",
        "cite_key": "BarbosaMendez2025b",
        "condition": "Nicotine vaccine preclinical",
        "scope_region": "brain reward circuitry",
        "scope_population": "rats",
        "value_source_sentence": "NIC6-TT vaccine reduces nicotine-seeking behavior and expression of neural markers"
      },
      {
        "n": null,
        "doi": "10.3389/fpsyt.2025.1548585",
        "value": "attenuated cocaine-induced behavioral sensitization",
        "cite_key": "BarbosaMendez2025a",
        "condition": "Cocaine vaccine preclinical",
        "scope_region": "brain reward circuitry",
        "scope_population": "rodents",
        "value_source_sentence": "COT-TT vaccine attenuates induction and expression of cocaine-induced behavioral sensitization"
      }
    ],
    "figure_id": "fig_sec11_vaccine_trial_outcomes",
    "comparison": "Vaccine efficacy across cocaine, nicotine, and opioid targets",
    "figure_type": "comparison_table",
    "n_definition": "Clinical: enrolled participants; Preclinical: number of animals per group",
    "source_cluster": 10,
    "taxonomic_level": "N/A",
    "homogeneity_check": "MAJOR CAVEAT: Comparison mixes preclinical (rodent) and clinical (human) data across different target substances and vaccine platforms. Preclinical efficacy consistently exceeds clinical results. Direct cross-study comparison of effect magnitudes is inappropriate."
  },
  "section_id": "section_12_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
  "target_ref": "wiki_page:computationalreviewaddiction-12",
  "review_repo": "ComputationalReviewAddiction",
  "section_ref": "wiki_page:computationalreviewaddiction-12",
  "source_path": "evidence/section_12_evidence.json",
  "source_refs": [
    "paper:paper-351cd3c3dc6c",
    "paper:paper-be1e9c17455b",
    "paper:paper-c1b82a5da4fd",
    "paper:paper-ec9024871511"
  ],
  "section_title": "Synthesis: An Evidence Scorecard for Addiction Neuroscience",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d95cfb705572",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}