Conservation of PV interneuron transcriptomic types across species

Both BICCN studies agree that PV interneuron subclasses are conserved across mouse, marmoset, and human, but human cortex shows expanded molecular diversity within these conserved types. This has implications for using mouse models to study human PV interneuron subtypes.

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1038/s41586-021-03950-0",
      "value": "conserved hierarchical organization",
      "method": "integrated multi-omic profiling",
      "metric": "Cross-species conservation of PV types",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "consensus taxonomy across species",
      "scope_region": "primary motor cortex",
      "study_system": "mouse, marmoset, human primary motor cortex",
      "taxonomic_level": "subclass to type level",
      "scope_population": "all cell types",
      "value_source_sentence": "cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human",
      "experimental_conditions": "BICCN multimodal atlas"
    },
    {
      "n": 0,
      "doi": "10.1038/s41586-021-03465-8",
      "value": "conserved subclasses, expanded human diversity",
      "method": "multi-modal cross-species analysis",
      "metric": "Species-specific vs conserved features",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "cells profiled across species",
      "scope_region": "motor cortex",
      "study_system": "human, marmoset, mouse motor cortex",
      "taxonomic_level": "subclass to cluster",
      "scope_population": "all cell types",
      "value_source_sentence": "Comparative cellular analysis of motor cortex in human, marmoset and mouse reveals conserved and divergent features.",
      "experimental_conditions": "snRNA-seq, spatial transcriptomics, epigenomics"
    }
  ],
  "comparison_id": "cross-species-pv-conservation",
  "comparison_name": "Conservation of PV interneuron transcriptomic types across species",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "Both BICCN studies agree that PV interneuron subclasses are conserved across mouse, marmoset, and human, but human cortex shows expanded molecular diversity within these conserved types. This has implications for using mouse models to study human PV interneuron subtypes.",
  "homogeneity_check": {
    "caveats": [
      "Both studies focus on motor cortex; generalization to other cortical areas uncertain",
      "Qualitative rather than quantitative comparison of conservation"
    ],
    "n_definition_uniform": "true",
    "scope_region_uniform": "true",
    "taxonomic_level_uniform": "false",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "heatmap"
}

[
  "paper:paper-pm-34616062",
  "paper:paper-pm-34616075"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}