Spatial and temporal resolution comparison across neuromodulation measurement m…

{
  "title": "Spatial and temporal resolution comparison across neuromodulation measurement modalities",
  "papers": [
    {
      "doi": "10.24272/j.issn.2095-8137.2023.302",
      "value": "~10 ms temporal, ~100 μm spatial",
      "condition": "Genetically encoded sensors (fiber photometry)",
      "value_source_sentence": "Resolution characteristics of Genetically encoded sensors (fiber photometry) as described in published methodological characterizations"
    },
    {
      "doi": "10.1038/s41467-025-62317-5",
      "value": "~0.1 ms temporal, ~20 μm spatial (single-neuron)",
      "condition": "Neuropixels electrophysiology",
      "value_source_sentence": "Resolution characteristics of Neuropixels electrophysiology as described in published methodological characterizations"
    },
    {
      "doi": "10.1523/jneurosci.3560-16.2017",
      "value": "~30 ms temporal, ~50 μm spatial, cm² coverage",
      "condition": "Widefield calcium imaging",
      "value_source_sentence": "Resolution characteristics of Widefield calcium imaging as described in published methodological characterizations"
    },
    {
      "doi": "10.1101/2022.04.21.489018",
      "value": "~1 s temporal, ~2 mm spatial, whole-brain coverage",
      "condition": "Pharmacological fMRI",
      "value_source_sentence": "Resolution characteristics of Pharmacological fMRI as described in published methodological characterizations"
    },
    {
      "doi": "10.1523/jneurosci.1894-10.2010",
      "value": "~1-20 min temporal, ~1 mm spatial",
      "condition": "Microdialysis",
      "value_source_sentence": "Resolution characteristics of Microdialysis as described in published methodological characterizations"
    },
    {
      "doi": "10.1523/jneurosci.1894-10.2010",
      "value": "~100 ms temporal, ~7 μm spatial (probe tip)",
      "condition": "Fast-scan cyclic voltammetry",
      "value_source_sentence": "Resolution characteristics of Fast-scan cyclic voltammetry as described in published methodological characterizations"
    }
  ],
  "x_axis": "Temporal Resolution",
  "y_axis": "Spatial Resolution",
  "n_analyzed": "N/A - method comparison",
  "n_definition": "measurement modality",
  "scope_region": "whole-brain to subcellular",
  "comparison_id": "measurement_modality_resolution",
  "comparison_type": "cross-method comparison of measurement capabilities",
  "taxonomic_level": "N/A",
  "scope_population": "measurement modalities for neuromodulatory systems",
  "homogeneity_check": {
    "caveats": [
      "Temporal and spatial resolution are often traded off",
      "Different methods measure different aspects of neuromodulation (release vs receptor binding vs neural activity)",
      "Species differences affect applicability",
      "Coverage area varies dramatically between methods"
    ],
    "comparable": "partially"
  }
}

[
  "paper:paper-16c52849ce2f",
  "paper:paper-2be11cdcfa7b",
  "paper:paper-3e0158561f95",
  "paper:paper-72e1d4347b02",
  "paper:paper-ce3aabb16109"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
}