{
"title": "Reinstatement Magnitude Across Trigger Types (Cue vs Stress vs Drug-Primed)",
"papers": [
{
"doi": "10.1124/jpet.121.000524",
"value": "The selective NOPr agonist SCH221510 but not naloxone decreased cocaine-primed reinstatement",
"cite_key": "Hillhouse2021",
"value_source_sentence": "The selective NOPr agonist SCH221510 but not naloxone decreased cocaine-primed reinstatement"
},
{
"doi": "10.1523/JNEUROSCI.0773-16.2016",
"value": "Activation of vmPFC neurons with the Gq-DREADD reduced reinstatement of cocaine seeking elicited by cocaine-associated cues, but not by cocaine itself",
"cite_key": "Augur2016",
"value_source_sentence": "Activation of vmPFC neurons with the Gq-DREADD reduced reinstatement of cocaine seeking elicited by cocaine-associated cues, but not by cocaine itself"
},
{
"doi": "10.3389/fnbeh.2023.1200392",
"value": "Furthermore, innate high levels of motor impulsivity were associated with higher drug use and increased vulnerability to cocaine-primed reinstatement ",
"cite_key": "Arrondeau2023",
"value_source_sentence": "Furthermore, innate high levels of motor impulsivity were associated with higher drug use and increased vulnerability to cocaine-primed reinstatement of drug-seeking"
},
{
"doi": "10.1016/j.biopsych.2015.07.002",
"value": "Animals re-exposed to psychosocial stress-predictive cues exhibited increased serum corticosterone and significantly greater reinstatement of cocaine ",
"cite_key": "Manvich2016",
"value_source_sentence": "Animals re-exposed to psychosocial stress-predictive cues exhibited increased serum corticosterone and significantly greater reinstatement of cocaine seeking than the control group, and active coping behaviors during social defeat episodes were associated with subsequent reinstatement magnitude"
},
{
"doi": "10.1007/s00213-011-2585-9",
"value": "<h4>Results</h4>Fenfluramine decreased yohimbine- and pellet-priming-induced reinstatement",
"cite_key": "Pickens2012",
"value_source_sentence": "<h4>Results</h4>Fenfluramine decreased yohimbine- and pellet-priming-induced reinstatement"
},
{
"doi": "10.1038/s41398-026-03954-2",
"value": "NAC significantly reduced cocaine-seeking behavior on the first day of extinction but not in subsequent extinction sessions",
"cite_key": "Huang2026a",
"value_source_sentence": "NAC significantly reduced cocaine-seeking behavior on the first day of extinction but not in subsequent extinction sessions"
},
{
"doi": "10.1016/j.neulet.2023.137237",
"value": "SR 21502 significantly reduced cue-induced reinstatement of methamphetamine-seeking",
"cite_key": "Ranaldi2023",
"value_source_sentence": "SR 21502 significantly reduced cue-induced reinstatement of methamphetamine-seeking"
},
{
"doi": "10.1016/j.pnpbp.2021.110462",
"value": "After cannabidiol 20 mg/kg treatment, increased levels of CB1 receptor protein were found in the prelimbic and orbitofrontal regions of the prefrontal",
"cite_key": "Lujan2022",
"value_source_sentence": "After cannabidiol 20 mg/kg treatment, increased levels of CB1 receptor protein were found in the prelimbic and orbitofrontal regions of the prefrontal cortex, and in the ventral striatum; an effect paralleled by a reduction of striatal ∆FosB accumulation and an increment of GluR2 AMPA receptor subun"
}
],
"n_analyzed": "As reported per study",
"description": "Comparison of lever-pressing during reinstatement tests across different trigger modalities",
"n_definition": "Rats completing extinction criteria and reinstatement testing",
"scope_region": "N/A - behavioral output",
"comparison_id": "fig4_reinstatement_modalities",
"taxonomic_level": "Species-specific (rat)",
"scope_population": "Male adult rats with prior cocaine SA experience",
"homogeneity_check": {
"caveats": [
"Extinction criteria vary across labs",
"Drug priming doses differ",
"Stress paradigms not equivalent (footshock vs yohimbine vs social defeat)",
"Cue complexity varies (light vs light+tone vs compound cues)",
"Prior training histories differ in duration and drug access"
],
"comparable": false
}
}