Effect of Environmental Enrichment on Drug Self-Administration

{
  "title": "Effect of Environmental Enrichment on Drug Self-Administration",
  "papers": [
    {
      "doi": "10.1016/j.biopsych.2015.07.002",
      "value": "Animals re-exposed to psychosocial stress-predictive cues exhibited increased serum corticosterone and significantly greater reinstatement of cocaine ",
      "cite_key": "Manvich2016",
      "value_source_sentence": "Animals re-exposed to psychosocial stress-predictive cues exhibited increased serum corticosterone and significantly greater reinstatement of cocaine seeking than the control group, and active coping behaviors during social defeat episodes were associated with subsequent reinstatement magnitude"
    },
    {
      "doi": "10.1523/ENEURO.0447-25.2026",
      "value": "EE did not impact acquisition \nof fentanyl self-administration but reduced fentanyl intake during maintenance \nof self-administration and reduced the ",
      "cite_key": "Higginbotham2026",
      "value_source_sentence": "EE did not impact acquisition \nof fentanyl self-administration but reduced fentanyl intake during maintenance \nof self-administration and reduced the persistence of drug-seeking in \nextinction"
    },
    {
      "doi": "10.64898/2025.12.02.691896",
      "value": "EE did not impact acquisition \nof fentanyl self-administration but reduced fentanyl intake during maintenance \nof self-administration and reduced the ",
      "cite_key": "Higginbotham2025",
      "value_source_sentence": "EE did not impact acquisition \nof fentanyl self-administration but reduced fentanyl intake during maintenance \nof self-administration and reduced the persistence of drug-seeking in \nextinction"
    },
    {
      "doi": "10.1038/s41598-021-81966-2",
      "value": "Socially isolated rats showed elevated baseline CORT, gained significantly less weight across the study, were more active in response to a novel or fa",
      "cite_key": "Mastrogiovanni2021",
      "value_source_sentence": "Socially isolated rats showed elevated baseline CORT, gained significantly less weight across the study, were more active in response to a novel or familiar environment"
    },
    {
      "doi": "10.1016/j.physbeh.2025.114810",
      "value": "In the present study, motivation to consume 10 % sucrose was assessed with lever press responding (0",
      "cite_key": "Grimm2025",
      "value_source_sentence": "In the present study, motivation to consume 10 % sucrose was assessed with lever press responding (0"
    },
    {
      "doi": "10.1016/bs.irn.2024.08.003",
      "value": "These alterations include reduced ethanol consumption, diminished operant self-administration, attenuated behavioral sensitization, and enhanced condi",
      "cite_key": "Unknown2024a",
      "value_source_sentence": "These alterations include reduced ethanol consumption, diminished operant self-administration, attenuated behavioral sensitization, and enhanced conditioned place preference"
    },
    {
      "doi": "10.1111/jnc.70181",
      "value": "Specifically, males exhibited a persistent ESI-induced downregulation of BDNF signaling paralleled by alterations in endocytic-recycling mechanisms me",
      "cite_key": "DiTrapano2025",
      "value_source_sentence": "Specifically, males exhibited a persistent ESI-induced downregulation of BDNF signaling paralleled by alterations in endocytic-recycling mechanisms mediated by Rab5-Rab11, suggesting increased TrkB sorting and reduced neuroplasticity"
    },
    {
      "doi": "10.1016/j.neuropharm.2024.109971",
      "value": "EE mice demonstrated increased social dominance and reduced motivation for appetitive taste stimuli",
      "cite_key": "Rae2024",
      "value_source_sentence": "EE mice demonstrated increased social dominance and reduced motivation for appetitive taste stimuli"
    }
  ],
  "n_analyzed": "As reported per study",
  "description": "Comparison of drug self-administration between enriched vs isolated/standard housing across studies",
  "n_definition": "Number of animals per housing condition completing SA protocol",
  "scope_region": "N/A - behavioral measure",
  "comparison_id": "fig2_enrichment_effect",
  "source_cluster": 5,
  "taxonomic_level": "Species-specific (rat)",
  "scope_population": "Predominantly male rats",
  "homogeneity_check": {
    "caveats": [
      "Enrichment protocols vary dramatically - toys, running wheels, social housing, or combinations",
      "Timing of enrichment differs - pre-exposure, concurrent with SA, or both",
      "Different drugs studied across papers",
      "Fixed vs progressive ratio schedules not always comparable",
      "Some studies use isolation vs pair housing, others use enriched vs standard"
    ],
    "comparable": false
  }
}

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  "paper:paper-556e757b1d89",
  "paper:paper-730173ae2841",
  "paper:paper-77dc97c2d383",
  "paper:paper-7b97cf68fce1",
  "paper:paper-a276490f9e17",
  "paper:paper-a86ae3133090",
  "paper:paper-fba0827b20b9"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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