Version history

{
  "kind": "infographic",
  "prompt": "SST interneurons gate the balance between intrahippocampal (CA3-CA1) and extrahippocampal (EC-CA1) inputs. Suppressing SST cells favors EC inputs while suppressing PV cells favors CA3 inputs. This bidirectional gating may underlie encoding vs retrieval mode switching.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1016/j.celrep.2021.110159",
        "value": "SST suppression: increases EC-CA1 coupling; PV suppression: increases CA3-CA1 coupling",
        "method": "chemogenetics + in vivo LFP",
        "metric": "EC-CA1 vs CA3-CA1 coupling",
        "cite_key": "AeryJones2021",
        "condition": "DG/CA3 SST vs PV suppression",
        "study_system": "mouse",
        "value_source_sentence": "Suppressing PV+ interneurons increases local field potential signatures of coupling from CA3 to CA1 and decreases signatures of coupling from entorhinal cortex to CA1; suppressing SST+ interneurons has the opposite effect."
      },
      {
        "doi": "10.3389/fnsys.2015.00110",
        "value": "O-LM cells gate EC input to distal dendrites; bistratified cells modulate CA3 Schaffer collateral input",
        "method": "network model",
        "metric": "O-LM gating of EC vs CA3 input",
        "cite_key": "Ferguson2015",
        "condition": "theta oscillations",
        "study_system": "computational",
        "value_source_sentence": "Network models provide insights into how oriens-lacunosum-moleculare and bistratified cell interactions may coordinate hippocampal theta activity."
      },
      {
        "doi": "10.1002/hipo.20661",
        "value": "O-LM activation favors retrieval by suppressing EC input and allowing CA3-driven recall",
        "method": "CA1 microcircuit model",
        "metric": "Encoding vs retrieval mode",
        "cite_key": "Cutsuridis2010",
        "condition": "encoding/retrieval dynamics",
        "study_system": "computational",
        "value_source_sentence": "Encoding and retrieval in a model of the hippocampal CA1 microcircuit."
      }
    ],
    "comparison_id": "sst-information-flow-gating",
    "comparison_name": "SST Interneurons Gate Information Flow in Hippocampal Circuits",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "SST interneurons gate the balance between intrahippocampal (CA3-CA1) and extrahippocampal (EC-CA1) inputs. Suppressing SST cells favors EC inputs while suppressing PV cells favors CA3 inputs. This bidirectional gating may underlie encoding vs retrieval mode switching.",
    "homogeneity_check": {
      "caveats": "Mix of experimental (in vivo) and computational studies. The experimental paper uses bulk SST suppression in DG/CA3, while computational models specifically target O-LM cells in CA1. The gating direction (SST suppression favors EC input) is consistent across approaches but tested at different circuit levels.",
      "comparable": false,
      "n_definition": "animals (experimental) vs simulation runs (computational)",
      "scope_region": "hippocampal CA1 and DG/CA3",
      "taxonomic_level": "mixed — broad SST vs subtype-specific",
      "scope_population": "SST+ interneurons (bulk) or O-LM cells (models)"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_09_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_09_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-09",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-09",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-07828f662237",
    "paper:paper-6033afc53a97",
    "paper:paper-a6b48e55fff8"
  ],
  "section_title": "Hippocampal SST Interneurons",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_09_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}