Escalation of Drug Intake Across Extended Access Models

{
  "title": "Escalation of Drug Intake Across Extended Access Models",
  "papers": [
    {
      "doi": "10.1038/npp.2012.67",
      "value": "Moreover, inhibition of monoamine oxidase with daily administration of phenelzine increased nicotine",
      "cite_key": "Cohen2012b",
      "value_source_sentence": "Moreover, inhibition of monoamine oxidase with daily administration of phenelzine increased nicotine intake by ≈ 50%"
    },
    {
      "doi": "10.3389/fnbeh.2023.1200392",
      "value": "Furthermore, innate high levels of motor impulsivity were associated with higher drug use and increased vulnerability to cocaine-primed reinstatement ",
      "cite_key": "Arrondeau2023",
      "value_source_sentence": "Furthermore, innate high levels of motor impulsivity were associated with higher drug use and increased vulnerability to cocaine-primed reinstatement of drug-seeking"
    },
    {
      "doi": "10.1038/s41386-024-01940-0",
      "value": "We trained Long-Evans outbred rats (n = 96) to self-administer 20% ethanol, and then introduced response-contingent footshock",
      "cite_key": "McDonald2024",
      "value_source_sentence": "We trained Long-Evans outbred rats (n = 96) to self-administer 20% ethanol, and then introduced response-contingent footshock"
    }
  ],
  "n_analyzed": "Varies by study - typically subsets that met inclusion criteria",
  "description": "Comparison of escalation magnitude across different drugs and access paradigms",
  "n_definition": "Number of rats completing full extended access protocol",
  "scope_region": "Nucleus accumbens/VTA circuit (behavioral output)",
  "comparison_id": "fig1_escalation_models",
  "source_cluster": 5,
  "taxonomic_level": "Species-specific (rat)",
  "scope_population": "Male adult rats (mostly Sprague-Dawley/Wistar)",
  "homogeneity_check": {
    "caveats": [
      "Different drugs (cocaine, heroin, nicotine, methamphetamine) have different pharmacokinetics",
      "Extended access duration varies (6h, 12h, 21h per session)",
      "Number of sessions varies (10-50 days)",
      "Rat strain differences affect baseline intake",
      "Unit dose varies across studies making direct comparisons difficult"
    ],
    "comparable": false
  }
}

[
  "paper:paper-be4df6a9c802",
  "paper:paper-ecec58a8ddac",
  "paper:paper-f2268233a56e"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}