Version history

{
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  "prompt": "SSRI treatment timeline: molecular vs clinical effects",
  "provider": "other",
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    "title": "SSRI treatment timeline: molecular vs clinical effects",
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      {
        "doi": "10.1002/brb3.70755",
        "value": "30 day",
        "n_definition": "subjects",
        "scope_region": "brain-wide",
        "scope_population": "patients or animal subjects",
        "value_source_sentence": ", for 30 days), (2) Quetiapine (QET; 10 mg/kg/day, i."
      },
      {
        "doi": "10.3389/fnins.2022.809269",
        "value": "1 week",
        "n_definition": "subjects",
        "scope_region": "brain-wide",
        "scope_population": "patients or animal subjects",
        "value_source_sentence": " Participants performed a modified version of an emotional flanker task before drug administration, after a single dose, after 1 week of SSRI intake, and after a 1-month wash-out period."
      },
      {
        "doi": "10.1016/j.neuropharm.2021.108447",
        "value": "70%",
        "n_definition": "subjects",
        "scope_region": "brain",
        "scope_population": "patients",
        "value_source_sentence": " The magnitude of regional 5-HTT occupancy by antidepressants was 70% or greater across cortical and sub-cortical regions, consistent with the magnitude of 5-HTT occupancy observed in mid-life depressed patients."
      }
    ],
    "figure_id": "fig_sec6_ssri_timecourse",
    "n_analyzed": null,
    "description": "Comparison of immediate serotonin transporter occupancy (hours), autoreceptor desensitization (days), neuroplastic changes (weeks), and clinical response (weeks) across studies.",
    "comparison_type": "temporal comparison",
    "taxonomic_level": "biological process",
    "homogeneity_check": {
      "caveats": [
        "Different SSRI compounds across studies (fluoxetine, citalopram, sertraline, etc.)",
        "Different doses and treatment durations",
        "Human vs animal studies have different temporal scales",
        "Different outcome measures (transporter occupancy, firing rate, behavioral response)",
        "Acute vs chronic measurement timepoints differ"
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    }
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  "section_title": "Serotonin: The Most Complex Modulatory System",
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