Details

kind
infographic
prompt
The PV-interneuron-gamma-oscillation link does not translate cleanly to consistent clinical EEG/MEG findings, suggesting the cell-to-network relationship is complex and non-linear.
provider
other
section_id
section_13_evidence_package
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json
target_ref
wiki_page:computationalreviewpv-13
review_repo
ComputationalReviewPV
section_ref
wiki_page:computationalreviewpv-13
source_path
evidence/section_13_evidence_package.json
section_title
Cross-Cluster Synthesis: What Replicates, What Is Contested, What Is Untested
generation_status
complete
review_bundle_ref
analysis_bundle:ab-e6261c8263e7
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json
commit_sha
df9fc7e8d455b084152c9d713558dae0013cef21
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (3)
raw_fields
{
  "papers": [
    {
      "n": 2133,
      "doi": "10.1038/s41537-025-00596-z",
      "value": "12",
      "method": "Systematic review and meta-analysis",
      "metric": "Number of studies showing gamma power increase",
      "n_analyzed": 43,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "Studies included in qualitative synthesis",
      "scope_region": "Whole brain/multiple regions",
      "study_system": "EEG/MEG recordings in schizophrenia",
      "taxonomic_level": "gamma frequency band (30-100 Hz)",
      "scope_population": "Schizophrenia patients vs controls",
      "value_source_sentence": "in 12 studies gamma power was increased, involving the whole brain (N = 3), multiple regions (N = 6) or only frontal (N = 1), central (n = 1) and temporal (N = 1) areas",
      "experimental_conditions": "Resting-state recordings"
    },
    {
      "n": 2133,
      "doi": "10.1038/s41537-025-00596-z",
      "value": "13",
      "method": "Systematic review",
      "metric": "Number of studies showing no difference",
      "n_analyzed": 43,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "Studies included in qualitative synthesis",
      "scope_region": "Variable",
      "study_system": "EEG/MEG recordings in schizophrenia",
      "taxonomic_level": "gamma frequency band (30-100 Hz)",
      "scope_population": "Schizophrenia patients vs controls",
      "value_source_sentence": "one study revealed mixed results and 13 studies showed no differences.",
      "experimental_conditions": "Resting-state recordings"
    }
  ],
  "comparison_id": "gamma-oscillation-consistency",
  "comparison_name": "Gamma oscillation findings in schizophrenia: direction and consistency of effects",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "The PV-interneuron-gamma-oscillation link does not translate cleanly to consistent clinical EEG/MEG findings, suggesting the cell-to-network relationship is complex and non-linear.",
  "homogeneity_check": {
    "caveats": [
      "Studies used different EEG/MEG setups and analysis methods",
      "Medication status varied across studies"
    ],
    "n_definition_uniform": "true",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "grouped bar"
}
source_refs
[
  "paper:paper-1aa62508f29b"
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

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