GABA reversal potential at AIS vs perisomatic sites across studies

The polarity of chandelier cell/axo-axonic inhibition at the AIS remains debated, with evidence for both depolarizing and hyperpolarizing effects in different cortical regions, having major implications for whether chandelier cells are excitatory or inhibitory

{
  "papers": [
    {
      "n": 0,
      "doi": "10.3389/neuro.04.015.2009",
      "value": "depolarized from rest",
      "method": "perforated patch and cell-attached recordings",
      "metric": "EGABA at AIS (chandelier cell PSP reversal)",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "paired recordings",
      "scope_region": "somatosensory cortex upper layers",
      "study_system": "mouse somatosensory cortex",
      "taxonomic_level": "fine type",
      "scope_population": "chandelier cell to pyramidal cell pairs",
      "value_source_sentence": "In both perforated patch and cell-attached configurations, chandelier PSPs have in every case a reversal potential that is depolarized from rest.",
      "experimental_conditions": "Nkx2.1Cre MADM mice, acute slices"
    },
    {
      "n": 0,
      "doi": "10.1113/jphysiol.2014.275719",
      "value": "-73.6 mV",
      "method": "gramicidin perforated patch recordings",
      "metric": "EGABA at AIS",
      "n_analyzed": null,
      "ci_or_error": "± 1.2 mV",
      "text_access": "fulltext",
      "n_definition": "recordings",
      "scope_region": "piriform cortex",
      "study_system": "mouse piriform cortex",
      "taxonomic_level": "fine type",
      "scope_population": "axo-axonic synapses on excitatory neurons",
      "value_source_sentence": "We found that the GABA reversal potential (EGABA) was -73.6 ± 1.2 mV when induced at the AIS and -72.8 ± 1.1 mV when induced at the perisomatic site.",
      "experimental_conditions": "VGAT-ChR2-YFP mice, gramicidin perforated patch"
    }
  ],
  "comparison_id": "gaba-reversal-potential-ais-perisomatic",
  "comparison_name": "GABA reversal potential at AIS vs perisomatic sites across studies",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "The polarity of chandelier cell/axo-axonic inhibition at the AIS remains debated, with evidence for both depolarizing and hyperpolarizing effects in different cortical regions, having major implications for whether chandelier cells are excitatory or inhibitory",
  "homogeneity_check": {
    "caveats": [
      "Different brain regions: neocortex vs piriform cortex",
      "Different recording methods: perforated patch/cell-attached vs gramicidin perforated patch",
      "Paper A reports qualitative direction while Paper B reports quantitative value"
    ],
    "n_definition_uniform": "true",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "forest plot"
}

[
  "paper:paper-6bf445de772c",
  "paper:paper-c803cdbd5cbd"
]

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    "Local review repositories are read-only inputs.",
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