Version history

{
  "kind": "infographic",
  "prompt": "How different computational and experimental approaches identify the specific contributions of SST (OLM) and PV interneurons to theta-gamma nested oscillations, a cross-frequency coupling pattern critical for hippocampal function.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1523/JNEUROSCI.3150-15.2016",
        "value": "65-75 Hz at 32°C, PING mechanism",
        "method": "optogenetics + in vitro electrophysiology",
        "metric": "Intrinsic CA1 gamma frequency",
        "cite_key": "Butler2016",
        "condition": "hippocampal slice, CaMKIIα-ChR2",
        "study_system": "mouse",
        "value_source_sentence": "The results suggest the presence of a single gamma rhythm generator with a frequency range of 65-75 Hz at 32°C"
      },
      {
        "doi": "10.1371/journal.pcbi.1010094",
        "value": "OLM and PV interactions produce theta-nested fast oscillations with distinct signatures",
        "method": "interneuronal network model",
        "metric": "OLM vs PV role in nested oscillations",
        "cite_key": "Via2022",
        "condition": "hippocampal circuit simulation",
        "study_system": "computational model",
        "value_source_sentence": "Interneuronal network model of theta-nested fast oscillations predicts different roles for OLM and PV interneurons"
      },
      {
        "doi": "10.1016/j.neuron.2017.02.017",
        "value": "CA3 and EC inputs interact with local dendritic inhibition to determine theta-gamma timing",
        "method": "high-density silicon probes in vivo",
        "metric": "Theta phase timing of CA1 neurons by afferent inputs",
        "cite_key": "FernandezRuiz2017",
        "condition": "hippocampus, multiple behavioral states",
        "study_system": "rat",
        "value_source_sentence": "upstream inputs interact with local mechanisms to determine theta phase timing of hippocampal neurons to support memory and spatial navigation"
      }
    ],
    "comparison_id": "theta-nested-gamma-mechanisms",
    "comparison_name": "Mechanisms of Theta-Nested Gamma Oscillations with Interneuron Contributions",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "How different computational and experimental approaches identify the specific contributions of SST (OLM) and PV interneurons to theta-gamma nested oscillations, a cross-frequency coupling pattern critical for hippocampal function.",
    "homogeneity_check": {
      "caveats": [
        "Mix of in vitro, in vivo, and computational approaches",
        "Different species and preparations",
        "Gamma frequency ranges may differ across preparations",
        "Complementary rather than directly comparable"
      ],
      "comparable": false
    },
    "suggested_plot_type": "scatter"
  },
  "section_id": "section_10_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_10_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-10",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-10",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-257e18af2151",
    "paper:paper-8627dcdaacbc",
    "paper:paper-cad8564e622d"
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_10_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}