{
"papers": [
{
"doi": "10.1038/s41386-020-0643-x",
"value": "p < 0.001",
"method": "inferred from abstract",
"cite_key": "Lefevre2020",
"value_source_sentence": "94, p = 0.001), while both exposure patterns caused antinociceptive tolerance (Fig."
},
{
"doi": "10.3390/brainsci15090897",
"value": "2.5%",
"method": "inferred from abstract",
"cite_key": "Bao2025",
"value_source_sentence": "Fiber photometry combined with electroencephalogram/electromyogram recordings was employed to synchronously track NAc DA signal dynamics across different states of consciousness under sevoflurane anesthesia.<h4>Results</h4>Under 2.5% sevoflurane exposure, DA release in the NAc significantly increased during the initial 100 s of sevoflurane induction, which was designated as sevo on-1 (mean ± standard error of the mean [SEM]; baseline vs."
},
{
"doi": "10.1016/j.isci.2025.113921",
"value": "10%",
"method": "inferred from abstract",
"cite_key": "Xu2025",
"value_source_sentence": "1 Epidemiological studies have demonstrated that the prevalence of CPOP varies between 10% and 50% across different surgical populations, 2 , 3 with particularly elevated incidence rates following spe"
},
{
"doi": "10.1016/j.ebiom.2026.106219",
"value": "p < 0.001",
"method": "inferred from abstract",
"cite_key": "Edvardsson2026",
"value_source_sentence": "Whether recently approved incretin polyagonists can modulate cocaine-related behaviours through their capacity to simultaneously engage multiple appetite-regulating peptide receptor pathways remains unexplored.<h4>Methods</h4>Here we investigated whether tirzepatide, a clinically approved long-acting dual glucose-dependent insulinotropic polypeptide (GIP)/glucagon-like peptide 1 (GLP-1) receptor agonist, alters cocaine-related behavioural and neurochemical responses in male rodents.<h4>Findings</h4>We found that tirzepatide produced dose-dependent reductions in cocaine self-administration (P < 0.001) and diminished cocaine-evoked dopamine responses, as evidenced by attenuated locomotor stimulation (P < 0.001), conditioned place preference (P < 0.001), and accumbal dopamine levels (P < 0.01) across two cocaine doses."
}
],
"x_axis": "Recording method",
"y_axis": "DA signal change (ΔF/F or nM)",
"n_analyzed": "varies by study",
"n_definition": "recording sessions or animals",
"scope_region": "nucleus accumbens",
"comparison_name": "DA transient amplitude during drug self-administration across methods",
"comparison_type": "cross-method comparison",
"taxonomic_level": "not applicable",
"scope_population": "dopamine terminals",
"homogeneity_check": "Methods differ fundamentally (photometry vs dLight vs microdialysis), making direct comparison of magnitudes misleading. Temporal resolution differs by orders of magnitude. Comparison is valid for pattern (phasic vs tonic) but not magnitude."
}