{
"papers": [
{
"doi": "10.1016/j.biopsych.2025.06.027",
"value": "significant change",
"method": "electrophysiology or photometry",
"cite_key": "Barry2026",
"value_source_sentence": "HDAC5 significantly increased inhibitory synaptic transmission onto PrL deep-layer pyramidal neurons and reduced the induction of FOS-positive neurons in the cocaine SA environment."
},
{
"doi": "10.3389/fnins.2025.1507747",
"value": "significant change",
"method": "electrophysiology or photometry",
"cite_key": "He2025b",
"value_source_sentence": "<h4>Results</h4>Dezocine significantly reduced withdrawal symptoms and prevented CPP reinstatement, indicating its potential to alleviate addiction behaviors."
},
{
"doi": "10.1016/j.pbb.2024.173931",
"value": "significant change",
"method": "electrophysiology or photometry",
"cite_key": "Schneider2025",
"value_source_sentence": "Heroin-treated rats showed a significant decrease in CRF1 receptor protein expression in the ventral tegmental area (VTA) and an increase in the nucleus accumbens (NAc) but no changes in the prefrontal cortex (PFC), insula, dorsal striatum (dSTR), dorsal hippocampus (dHippo), anterior hypothalamus (HYPTH), amygdala, or substantia nigra (SN) as compared to saline-treated rats."
},
{
"doi": "10.3389/fncel.2022.844243",
"value": "20%",
"method": "electrophysiology or photometry",
"cite_key": "Siemsen2022",
"value_source_sentence": "Additionally, when relatively weak PFC stimulation is employed, ∼20% of NAcore neurons exhibit spike firing, suggesting that a subpopulation of NAcore neurons receives the majority of PrL inputs ( Fin"
},
{
"doi": "10.1523/jneurosci.3020-17.2019",
"value": "10 Hz",
"method": "electrophysiology or photometry",
"cite_key": "Benneyworth2019",
"value_source_sentence": "Optogenetic examination of circuit-specific plasticity showed that inhibition of infralimbic cortical input to the NAc shell blocked cocaine-primed reinstatement, whereas low-frequency stimulation (10 Hz) of this pathway in the absence of cocaine triggered a reduction in synaptic strength akin to that observed with cocaine, and was sufficient to promote reinstatement in the absence of a cocaine challenge."
},
{
"doi": "10.1111/adb.70084",
"value": "p < 0.01",
"method": "electrophysiology or photometry",
"cite_key": "Li2025b",
"value_source_sentence": "In addition, the ratio of p-GSK-3β to t-GSK-3β in the PFC, Hip and VTA of rats with behavioural sensitisation significantly decreased, and the expression of DAT decreased significantly (p < 0.01)."
},
{
"doi": "10.1007/s00213-022-06287-2",
"value": "significant change",
"method": "electrophysiology or photometry",
"cite_key": "Moorman2023",
"value_source_sentence": "During both cue- and, to a greater extent, cocaine-induced reinstatement, PL neurons exhibited significantly elevated responses, in line with previous studies demonstrating a role for the region in relapse."
}
],
"x_axis": "PFC subregion",
"y_axis": "Firing rate or calcium signal change",
"n_analyzed": "varies by study",
"n_definition": "neurons recorded or animals",
"scope_region": "prefrontal cortex subregions (PL, IL, OFC)",
"comparison_name": "PFC neural activity during extinction vs reinstatement across regions",
"comparison_type": "regional comparison",
"taxonomic_level": "anatomical subregion",
"scope_population": "pyramidal neurons",
"homogeneity_check": "PFC subregion boundaries vary across studies. Some use electrophysiology (single units) while others use fiber photometry (population signal). Behavioral paradigms differ (extinction training duration, reinstatement type)."
}