Anti-drug vaccine clinical and preclinical outcomes across target substances

{
  "title": "Anti-drug vaccine clinical and preclinical outcomes across target substances",
  "papers": [
    {
      "n": 266,
      "doi": "10.1080/21645515.2022.2140552",
      "value": "vaccinated groups 50 times more likely to be cocaine-free",
      "cite_key": "Scendoni2022",
      "condition": "Cocaine vaccine meta-analysis",
      "scope_region": "systemic (peripheral)",
      "scope_population": "cocaine-dependent patients",
      "value_source_sentence": "showed that vaccinated groups were 50 times more likely to cease cocaine"
    },
    {
      "n": 130,
      "doi": "10.3390/pharmaceutics14112368",
      "value": "IgA rather than IgG mediates protection",
      "cite_key": "Kosten2022",
      "condition": "Anti-cocaine vaccine antibody characterization",
      "scope_region": "systemic",
      "scope_population": "vaccinated subjects",
      "value_source_sentence": "Anti-Cocaine IgA Rather Than IgG Mediates Vaccine Protection from Cocaine Use"
    },
    {
      "n": null,
      "doi": "10.3390/brainsci15040364",
      "value": "reduced nicotine self-administration in rats",
      "cite_key": "BarbosaMendez2025b",
      "condition": "Nicotine vaccine preclinical",
      "scope_region": "brain reward circuitry",
      "scope_population": "rats",
      "value_source_sentence": "NIC6-TT vaccine reduces nicotine-seeking behavior and expression of neural markers"
    },
    {
      "n": null,
      "doi": "10.3389/fpsyt.2025.1548585",
      "value": "attenuated cocaine-induced behavioral sensitization",
      "cite_key": "BarbosaMendez2025a",
      "condition": "Cocaine vaccine preclinical",
      "scope_region": "brain reward circuitry",
      "scope_population": "rodents",
      "value_source_sentence": "COT-TT vaccine attenuates induction and expression of cocaine-induced behavioral sensitization"
    }
  ],
  "figure_id": "fig_sec11_vaccine_trial_outcomes",
  "comparison": "Vaccine efficacy across cocaine, nicotine, and opioid targets",
  "figure_type": "comparison_table",
  "n_definition": "Clinical: enrolled participants; Preclinical: number of animals per group",
  "taxonomic_level": "N/A",
  "homogeneity_check": "MAJOR CAVEAT: Comparison mixes preclinical (rodent) and clinical (human) data across different target substances and vaccine platforms. Preclinical efficacy consistently exceeds clinical results. Direct cross-study comparison of effect magnitudes is inappropriate."
}

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  "paper:paper-be1e9c17455b",
  "paper:paper-c1b82a5da4fd",
  "paper:paper-ec9024871511"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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