{
"papers": [
{
"n": 6,
"doi": "10.3390/ph18101513",
"value": "52 ± 0.5",
"metric": "Cytokine level or microglial activation marker",
"cite_key": "Mende2025",
"text_access": "fulltext",
"study_system": "rat",
"value_source_sentence": "Behavioral Measurements The tail-flick analgesia assay was performed using hot-water immersion at 52 ± 0.5 °C before and after a 5-day morphine infusion."
},
{
"n": null,
"doi": "10.1016/j.addicn.2024.100194",
"value": "4 pa",
"metric": "Cytokine level or microglial activation marker",
"cite_key": "Melkumyan2025",
"text_access": "fulltext",
"study_system": "review",
"value_source_sentence": "Downstream signaling factors in the TLR4 pathway may also be involved in alcohol effects in the CeA."
},
{
"n": 17,
"doi": "10.1126/sciadv.adu5874",
"value": "P = 0.0049",
"metric": "Cytokine level or microglial activation marker",
"cite_key": "Xiao2026",
"text_access": "fulltext",
"study_system": "rat",
"value_source_sentence": "However, the age at seizure onset was older in the post–COVID-19 nonactive TLE group compared to the active group ( P = 0.0049)."
},
{
"n": null,
"doi": "10.3389/fimmu.2025.1671578",
"value": "13 pa",
"metric": "Cytokine level or microglial activation marker",
"cite_key": "Han2025",
"text_access": "fulltext",
"study_system": "rat",
"value_source_sentence": "Rank Keyword Counts Rank Keyword Counts 1 inflammation 710 11 vagus nerve 134 2 neuroinflammation 495 12 cytokine 131 3 microglia 402 13 pain 129 4 cytokines 325 14 multiple sclerosis 114 5 cholinergic anti-inflammatory pathway"
},
{
"n": 14,
"doi": "10.3390/ijms27041670",
"value": "p = 0.020",
"metric": "Cytokine level or microglial activation marker",
"cite_key": "Lorkiewicz2026",
"text_access": "fulltext",
"study_system": "rat",
"value_source_sentence": "Additionally, the type of viral infection was significantly associated only with depression severity at Stage 2, as assessed by the HADS ( p = 0.020)."
},
{
"n": 727,
"doi": "10.3389/fimmu.2025.1645991",
"value": "727 pa",
"metric": "Cytokine level or microglial activation marker",
"cite_key": "Yu2025",
"text_access": "fulltext",
"study_system": "rat",
"value_source_sentence": "Subsequent research, including a multicenter cohort study involving 1,727 participants, demonstrated a strong interaction between chronic depressive symptoms and elevated inflammation levels ( 59 – 61 )."
},
{
"n": 37,
"doi": "10.1038/s41398-026-03907-9",
"value": "p = 0.042",
"metric": "Cytokine level or microglial activation marker",
"cite_key": "Petit2026",
"text_access": "fulltext",
"study_system": "human",
"value_source_sentence": "116, p = 0.042)."
},
{
"n": 61,
"doi": "10.3390/brainsci14050435",
"value": "2 mg/kg",
"metric": "Cytokine level or microglial activation marker",
"cite_key": "Nagy2024",
"text_access": "fulltext",
"study_system": "rat",
"value_source_sentence": "During the first 3 days of postsurgical care, rats were administered meloxicam (2 mg/kg s."
}
],
"n_definition": "Variable across studies",
"scope_region": "Multiple brain regions",
"comparison_id": "fig_sec3_neuroimmune_evidence_strength",
"comparison_type": "evidence_strength_assessment",
"scope_population": "Microglia, astrocytes, neurons",
"homogeneity_check": {
"caveats": [
"Highly heterogeneous measures: cytokine levels, microglial morphology, TLR4 expression",
"Mix of brain regions, drug types, and exposure paradigms",
"This figure assesses evidence strength rather than comparing magnitudes",
"Designed as Type D summary figure highlighting thin evidence base"
],
"comparable": false
},
"suggested_plot_type": "evidence_scorecard"
}