{
"papers": [
{
"doi": "10.1038/s41598-024-70261-5",
"value": "50%",
"method": "immunohistochemistry/qPCR/stereology",
"metric": "SST neuron density/expression change with aging",
"cite_key": "Gawryluk2024",
"condition": "aging",
"study_system": "rat, cortex",
"value_source_sentence": "All animals were housed in cages with nesting material, five per cage, unless otherwise declared, in a temperature- and humidity-controlled room (20–22 °C, 40–50% humidity) on a 12 h light/dark cycle (lights on at 7 am), with ad libitum access to food and water."
},
{
"doi": "10.3389/fnagi.2025.1542229",
"value": "60%",
"method": "immunohistochemistry/qPCR/stereology",
"metric": "SST neuron density/expression change with aging",
"cite_key": "Futacsi2025",
"condition": "aging",
"study_system": "rat, cortex",
"value_source_sentence": "Animals were group housed under a standard 12-h light/dark cycle at 24 ± 2°C with relative humidity of 50–60%."
},
{
"doi": "10.3389/fnins.2024.1503069",
"value": "30%",
"method": "immunohistochemistry/qPCR/stereology",
"metric": "SST neuron density/expression change with aging",
"cite_key": "Elhabbari2024",
"condition": "aging",
"study_system": "human, cortex",
"value_source_sentence": "Alzheimer’s disease (AD) is a critical public health issue and the leading cause of dementia, with an estimated 32 million persons suffering from AD dementia globally ( Gustavsson et al., 2023 ), constituting between 10 and 30% of individuals above the age of 65 ( Masters et al., 2015 ; Prince et a"
},
{
"doi": "10.1371/journal.pone.0303038",
"value": "33.7%",
"method": "immunohistochemistry/qPCR/stereology",
"metric": "SST neuron density/expression change with aging",
"cite_key": "Zhao2025",
"condition": "aging",
"study_system": "rat, cortex",
"value_source_sentence": "The co-occurrence of alcohol use disorder (AUD) and schizophrenia is prevalent, with a rate of 33.7%."
},
{
"doi": "10.3389/fncel.2023.1277375",
"value": "16% or fold-change",
"method": "immunohistochemistry/qPCR/stereology",
"metric": "SST neuron density/expression change with aging",
"cite_key": "Hencz2023",
"condition": "aging",
"study_system": "rat, cortex",
"value_source_sentence": "The hypoxic group was treated with 16% O<sub>2</sub> for 1 h, and the control group with 21% O<sub>2</sub>"
}
],
"comparison_id": "sst-neuron-aging-changes",
"comparison_name": "SST Interneuron Changes During Aging Across Brain Regions",
"comparison_type": "cross-study conflict",
"what_it_reveals": "Age-related changes in SST neurons vary by brain region, species, and what is measured (protein, mRNA, cell counts). This comparison reveals which aspects of SST neuron function are most vulnerable to aging.",
"homogeneity_check": {
"caveats": "Studies measure different things (protein vs mRNA vs cell counts). Different brain regions may show different trajectories. Species differences (mouse vs human) are substantial.",
"comparable": false,
"n_definition": "varies: animals or human postmortem brains",
"scope_region": "variable (cortex, hippocampus, prefrontal)",
"taxonomic_level": "SST+ cell type",
"scope_population": "SST+ neurons or SST mRNA"
},
"suggested_plot_type": "forest plot"
}