Version history

{
  "kind": "infographic",
  "prompt": "Electrical coupling via gap junctions (connexin36) among SST/LTS interneurons is a consistent finding across multiple labs and species, enabling synchronous firing. The coupling is class-specific (SST-SST but not SST-PV) and strong enough to synchronize spikes.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1038/47035",
        "value": "strong electrical coupling within class; absent between classes",
        "method": "paired whole-cell recording",
        "metric": "LTS-LTS electrical coupling",
        "cite_key": "Gibson1999",
        "condition": "somatosensory cortex, layer 4, P13-16",
        "study_system": "rat",
        "value_source_sentence": "Paired-cell recordings showed that inhibitory neurons of the same type were strongly interconnected by electrical synapses, but electrical synapses between different inhibitory cell types were rare."
      },
      {
        "doi": "10.1152/jn.00283.2003",
        "value": "LTS cells electrically coupled; synchronize at theta frequencies",
        "method": "paired recording",
        "metric": "LTS network electrical coupling",
        "cite_key": "Beierlein2003",
        "condition": "somatosensory cortex, layer 4",
        "study_system": "mouse",
        "value_source_sentence": "Two dynamically distinct inhibitory networks in layer 4 of the neocortex."
      },
      {
        "doi": "10.1016/s0896-6273(01)00373-7",
        "value": "Cx36 knockout eliminates interneuron electrical coupling and synchronous activity",
        "method": "Cx36 knockout, paired recording",
        "metric": "Cx36-dependent electrical coupling",
        "cite_key": "Deans2001",
        "condition": "neocortex",
        "study_system": "mouse",
        "value_source_sentence": "Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36."
      },
      {
        "doi": "10.1152/jn.90691.2008",
        "value": "theta-frequency (3-10 Hz) synchronous firing proportional to coupling strength",
        "method": "paired recording, GIN transgenic",
        "metric": "SST/GIN cell electrical coupling and synchronization",
        "cite_key": "Fanselow2008",
        "condition": "somatosensory cortex, layer 2/3",
        "study_system": "mouse",
        "value_source_sentence": "Synchronous firing was often observed and its strength was directly proportional to the magnitude of electrical coupling between GIN cells."
      }
    ],
    "comparison_id": "sst-electrical-coupling",
    "comparison_name": "Electrical Coupling Among SST/LTS Interneurons: Properties and Functional Significance",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Electrical coupling via gap junctions (connexin36) among SST/LTS interneurons is a consistent finding across multiple labs and species, enabling synchronous firing. The coupling is class-specific (SST-SST but not SST-PV) and strong enough to synchronize spikes.",
    "homogeneity_check": {
      "caveats": [
        "Different species (rat vs mouse), different ages (juvenile vs adult), different layers"
      ],
      "n_definition": "paired recordings",
      "scope_region": "somatosensory cortex across studies",
      "scope_population": "LTS/SST/GIN interneurons"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_06_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_06_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-06",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-06",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-2825244ee6d0",
    "paper:paper-7b76a9ffb80b",
    "paper:paper-7fa9372405b6",
    "paper:paper-b2fe37fe47cf"
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_06_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}