Version history

{
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  "prompt": "Synthesis: An Evidence Scorecard for Addiction Neuroscience figure 5",
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        "value_source_sentence": "94,  p  = 0.34)."
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        "value_source_sentence": "FIGURE 3   NMDAR‐LTP at SCC synapses (a more contemporary view)."
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        "doi": "10.3390/biomedicines12112422",
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        "cite_key": "ValladolidAcebes2024",
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        "value_source_sentence": "60.   Park H."
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        "doi": "10.1016/j.neurot.2026.e00839",
        "value": "reduced by approximately 50%",
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        "value_source_sentence": "In subsequent Phase 1 studies, doses and ratios of xanomeline and trospium were varied to optimize tolerability, and indeed, cholinergic AEs induced by xanomeline were reduced by approximately 50% when co-administered with trospium at the optimal ratios [ 101 ]."
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        "value_source_sentence": "Elfn1  P  = 0.0168 unpaired  t  test; SYP  P  = 0."
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        "value_source_sentence": "However, up to 80% of PD patients also experience cognitive and psychiatric issues."
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    ],
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    "scope_population": "glutamatergic synapses onto DA neurons",
    "homogeneity_check": {
      "caveats": [
        "Different drugs of abuse (cocaine, morphine, ethanol) with different mechanisms",
        "Mix of single-exposure and chronic exposure paradigms",
        "Variable time points post-drug (24h to weeks)",
        "Different electrophysiology recording conditions across labs"
      ],
      "comparable": true
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  },
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  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
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  "review_repo": "ComputationalReviewAddiction",
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    "paper:paper-a6ea2acae5d7",
    "paper:paper-da4f25ec9d05",
    "paper:paper-fd92110f9b26"
  ],
  "section_title": "Synthesis: An Evidence Scorecard for Addiction Neuroscience",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
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}