Version history

{
  "kind": "infographic",
  "prompt": "The temporal offset between SST and PV neurogenesis is a key specification mechanism. Cross-study comparison reveals how consistently SST neurons are born before PV neurons across different experimental preparations and species.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1093/brain/awac271",
        "value": null,
        "method": "birthdating/fate mapping",
        "metric": "peak birthdating of SST vs PV interneurons",
        "cite_key": "Cheng2023",
        "condition": "developmental",
        "study_system": "human, cortex",
        "value_source_sentence": "Consistent with these findings, single-cell transcriptomic analyses of medial ganglionic eminence identified a distinct subpopulation of cells exhibiting perturbation in genes regulating neurogenesis, ciliogenesis, mitochondrial function and MAPK signalling in rabbits with IVH"
      },
      {
        "doi": "10.1093/cercor/bhq155",
        "value": null,
        "method": "birthdating/fate mapping",
        "metric": "peak birthdating of SST vs PV interneurons",
        "cite_key": "Miyoshi2011",
        "condition": "developmental",
        "study_system": "rat, cortex",
        "value_source_sentence": "Using inducible in vivo genetic fate mapping approaches, we found that interneuron precursors arising from the medial ganglionic eminence (MGE) and caudal ganglionic eminence (CGE) at E12"
      },
      {
        "doi": "10.1523/jneurosci.3550-15.2016",
        "value": null,
        "method": "birthdating/fate mapping",
        "metric": "peak birthdating of SST vs PV interneurons",
        "cite_key": "Torigoe2016",
        "condition": "developmental",
        "study_system": "rat, cortex",
        "value_source_sentence": "Although the specifications and laminar fate of medial ganglionic eminence-derived neocortical interneurons depend on their location of embryonic origin and birthdate, no similar causality of lateral/caudal ganglionic eminence (LGE/CGE)-derived neocortical interneurons is known"
      },
      {
        "doi": "10.1111/febs.70158",
        "value": null,
        "method": "birthdating/fate mapping",
        "metric": "peak birthdating of SST vs PV interneurons",
        "cite_key": "Vasan2025",
        "condition": "developmental",
        "study_system": "human, cortex",
        "value_source_sentence": "Despite variations in NPC differentiation kinetics and outcomes, proneural genes encoding basic helix-loop-helix (bHLH) transcription factors (TFs) have remained constant as the core drivers of neurogenesis and neuronal subtype specification from fly to human"
      },
      {
        "doi": "10.3390/ijms22105113",
        "value": null,
        "method": "birthdating/fate mapping",
        "metric": "peak birthdating of SST vs PV interneurons",
        "cite_key": "Kim2021",
        "condition": "developmental",
        "study_system": "mouse, cortex",
        "value_source_sentence": "We propose the protracted development of interneurons at each stage (neurogenesis, neuronal migration, and network integration), as a mechanism for increased complexity and cognitive flexibility in larger, gyrencephalic brains"
      },
      {
        "doi": "10.3389/fnins.2021.803107",
        "value": null,
        "method": "birthdating/fate mapping",
        "metric": "peak birthdating of SST vs PV interneurons",
        "cite_key": "Salamon2022",
        "condition": "developmental",
        "study_system": "human, cortex",
        "value_source_sentence": "Thus, neurogenesis can be conceptualized along two timescales of progenitors' capacity to (1) self-renew or differentiate into basal progenitors (BPs) or neurons or (2) specify their fate into distinct neuronal and glial subtypes which participate in the formation of six-layers"
      },
      {
        "doi": "10.1016/j.celrep.2015.09.079",
        "value": null,
        "method": "birthdating/fate mapping",
        "metric": "peak birthdating of SST vs PV interneurons",
        "cite_key": "Petros2015",
        "condition": "developmental",
        "study_system": "rat, cortex",
        "value_source_sentence": "Here, we use in vivo fate mapping and the manipulation of neurogenic location to demonstrate that apical versus basal neurogenesis influences the fate determination of major subgroups of cortical interneurons derived from the subcortical telencephalon"
      },
      {
        "doi": "10.1111/ejn.70136",
        "value": null,
        "method": "birthdating/fate mapping",
        "metric": "peak birthdating of SST vs PV interneurons",
        "cite_key": "Marin2025",
        "condition": "developmental",
        "study_system": "human, cortex",
        "value_source_sentence": "These studies identified many features in the development of human cortical interneurons that are shared with other mammals, along with distinctive features that seem characteristic of the primate brain, such as a previously unrecognised protracted period of neurogenesis and migration that extends t"
      }
    ],
    "comparison_id": "sst-pv-birthdating-timeline",
    "comparison_name": "SST vs PV Interneuron Birth Timing Across Studies",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "The temporal offset between SST and PV neurogenesis is a key specification mechanism. Cross-study comparison reveals how consistently SST neurons are born before PV neurons across different experimental preparations and species.",
    "homogeneity_check": {
      "caveats": "Different birthdating methods (BrdU, EdU, genetic fate mapping) may label different cell populations. Species differences (mouse vs rat) add variability.",
      "comparable": true,
      "n_definition": "varies: animals, sections, or cells counted",
      "scope_region": "cortex (various areas)",
      "taxonomic_level": "SST+ vs PV+ subtypes",
      "scope_population": "MGE-derived interneurons"
    },
    "suggested_plot_type": "timeline"
  },
  "section_id": "section_03_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_03_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-03",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-03",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-45e23c648159",
    "paper:paper-68853350b58e",
    "paper:paper-9fe88d4f840e",
    "paper:paper-a28eea820be3",
    "paper:paper-bb5efd4c161d",
    "paper:paper-e4e75dd71b03",
    "paper:paper-ee1f6d6fe65e",
    "paper:paper-fa9274f702c1"
  ],
  "section_title": "Developmental Origins and Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_03_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}