Version history

{
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  "prompt": "The Species Translation Problem: From Mouse Circuits to Human Therapeutics figure 3",
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      {
        "doi": "10.1038/s41398-025-03582-2",
        "value": "80%",
        "value_source_sentence": "Based on literature PET findings for striatal D<sub>2</sub>R occupancy in monotherapy, our model predicts that widely used antipsychotic medication combinations may exceed the optimal therapeutic window of 65-80% occupancy."
      },
      {
        "doi": "10.1177/0271678x251389042",
        "value": "25%",
        "value_source_sentence": "Rimonabant (1, 3 mg/kg, <i>n</i> = 1 for each) reduced [<sup>11</sup>C]OMAR non-displaceable binding potential by 25%-40% in CB1R-rich regions."
      },
      {
        "doi": "10.3390/cells13141230",
        "value": "92.8%",
        "value_source_sentence": "PET imaging indicated that a PDE10A enzyme occupancy of up to 92.8% was achieved with a ~24 h half-life.<h4>Conclusions</h4>The preclinical and clinical data presented here support the study of EM-221 in phase 2 trials of Tourette syndrome and other movement disorders."
      },
      {
        "doi": "10.1093/ijnp/pyaa071",
        "value": "59.2%",
        "value_source_sentence": "Mean D2 receptor occupancy for blonanserin tablets 8 mg/d (59.2%, n = 5) and 16 mg/d (66.3%, n = 9) was within the values for blonanserin patches: 10 mg/d (33.3%, n = 3), 20 mg/d (29.9%, n = 2), 40 mg/d (61.2%, n = 3), 60 mg/d (59.0%, n = 3), and 80 mg/d (69.9%, n = 3)."
      },
      {
        "doi": "10.1038/s41398-022-02187-3",
        "value": "80%",
        "value_source_sentence": "After treatment, average SERT occupancy in the SSRI + ICBT group was >80%, with positive associations between symptom improvement and occupancy in the nucleus accumbens, putamen and anterior cingulate cortex."
      }
    ],
    "figure_id": "fig_sec10_pet_receptor_occupancy",
    "n_analyzed": "typically 6-30 subjects per study",
    "description": "Comparison of receptor occupancy values (%) measured by PET for different neuromodulatory drugs at therapeutic doses in human brain.",
    "n_definition": "number of PET scans/subjects per study",
    "scope_region": "striatum and cortex (primary regions of interest for D2 and 5-HT)",
    "comparison_type": "PET receptor occupancy by drug class",
    "taxonomic_level": "N/A (human only)",
    "scope_population": "human patients and healthy volunteers",
    "homogeneity_check": "Generally COMPARABLE for same receptor/radioligand pairs. Different radioligands for same receptor may yield different absolute occupancy values due to different binding characteristics. Scanner resolution and reference region choices can affect quantification."
  },
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    "paper:paper-9860403e0024",
    "paper:paper-a4b0242c3f42",
    "paper:paper-f9ab952fd347"
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  "section_title": "The Species Translation Problem: From Mouse Circuits to Human Therapeutics",
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      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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