Comparison of treatment approaches for substance use disorders: evidence base a…

{
  "title": "Comparison of treatment approaches for substance use disorders: evidence base and outcomes",
  "papers": [
    {
      "n": null,
      "doi": "10.3390/medicines13010007",
      "value": "Pharmacotherapy for alcohol craving: established efficacy",
      "cite_key": "CheibubDavidMarin2026",
      "condition": "Pharmacotherapy (acamprosate, naltrexone, nalmefene)",
      "scope_region": "N/A - systemic",
      "scope_population": "AUD patients",
      "value_source_sentence": "Pharmacotherapy for alcohol craving reduction: efficacy of short-term treatments in alcohol use disorder"
    },
    {
      "n": null,
      "doi": "10.1101/2025.09.21.25335559",
      "value": "g = 0.52 for NIBS craving reduction",
      "cite_key": "Soleimani2025",
      "condition": "Neuromodulation (TMS/tDCS)",
      "scope_region": "dlPFC primarily",
      "scope_population": "SUD patients",
      "value_source_sentence": "Hedges' g = 0.52 for craving reduction across noninvasive brain stimulation protocols"
    },
    {
      "n": 17,
      "doi": "10.1001/jamanetworkopen.2026.0972",
      "value": "significantly increased long-term abstinence",
      "cite_key": "Johnson2026",
      "condition": "Psilocybin-assisted therapy",
      "scope_region": "5-HT2A mediated",
      "scope_population": "smokers seeking cessation",
      "value_source_sentence": "significantly increased long-term abstinence compared with nicotine patch"
    },
    {
      "n": 266,
      "doi": "10.1080/21645515.2022.2140552",
      "value": "50x more likely cocaine-free (high-titer subgroup only)",
      "cite_key": "Scendoni2022",
      "condition": "Anti-drug vaccines",
      "scope_region": "systemic (peripheral sequestration)",
      "scope_population": "cocaine-dependent patients",
      "value_source_sentence": "showed that vaccinated groups were 50 times more likely to cease cocaine use"
    }
  ],
  "figure_id": "fig_sec11_treatment_modality_comparison",
  "comparison": "Level of evidence across pharmacotherapy, neuromodulation, psychedelic-assisted therapy, and immunotherapy",
  "figure_type": "evidence_matrix",
  "n_definition": "Varies by modality: individual trial n vs meta-analytic pooled n",
  "source_cluster": 10,
  "taxonomic_level": "N/A",
  "homogeneity_check": "CRITICAL CAVEAT: This comparison spans fundamentally different treatment modalities targeting different stages of addiction (craving vs. drug access vs. circuit dynamics), different substances, different trial designs, and vastly different evidence maturity levels. This is a conceptual comparison of evidence breadth, not a head-to-head efficacy comparison."
}

[
  "paper:paper-3f5b6118b770",
  "paper:paper-c1b82a5da4fd",
  "paper:paper-d40d68acaac2",
  "paper:paper-e2c72ec1f4a3"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}