Version history

{
  "kind": "infographic",
  "prompt": "Nav1.1/PV interneuron dysfunction is a shared mechanism across Dravet syndrome epilepsy and Alzheimer's disease, suggesting PV cell excitability as a therapeutic convergence point",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1523/jneurosci.5270-06.2007",
        "value": "pronounced spike amplitude decrement in heterozygous PV cells",
        "method": "whole-cell patch clamp electrophysiology",
        "metric": "Spike output impairment in PV interneurons",
        "n_analyzed": 0,
        "ci_or_error": null,
        "text_access": "abstract_only",
        "n_definition": "neurons recorded in Scn1a knock-in mice",
        "scope_region": "neocortex",
        "study_system": "Scn1a knock-in mice, Dravet syndrome model",
        "taxonomic_level": "single cell type (PV fast-spiking)",
        "scope_population": "PV-positive interneurons",
        "value_source_sentence": "In heterozygous knock-in mice, trains of evoked action potentials in these fast-spiking, inhibitory cells exhibited pronounced spike amplitude decrement late in the burst.",
        "experimental_conditions": "heterozygous vs wild-type"
      },
      {
        "n": 0,
        "doi": "10.1016/j.cell.2012.02.046",
        "value": "decreased Nav1.1 levels in hAPP mice and AD patients",
        "method": "immunohistochemistry, western blot, EEG",
        "metric": "Nav1.1 protein levels in hAPP mice and AD patients",
        "n_analyzed": 0,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "hAPP transgenic mice and human AD postmortem tissue",
        "scope_region": "hippocampus and cortex",
        "study_system": "hAPP transgenic mice and human AD postmortem",
        "taxonomic_level": "single cell type (PV cells)",
        "scope_population": "PV-positive interneurons",
        "value_source_sentence": "hAPP mice and AD patients had decreased levels of the interneuron-specific and PV cell-predominant voltage-gated sodium channel subunit Nav1.1.",
        "experimental_conditions": "hAPP vs non-transgenic; AD vs control"
      },
      {
        "n": 0,
        "doi": "10.1073/pnas.1411131111",
        "value": "two major types of inhibitory neurons impaired in signal generation",
        "method": "whole-cell patch clamp recordings",
        "metric": "Impaired excitability of PV and SST interneurons in Dravet",
        "n_analyzed": 0,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "neurons recorded in DS mouse model",
        "scope_region": "cerebral cortex",
        "study_system": "Scn1a+/- Dravet syndrome mouse",
        "taxonomic_level": "two cell types (PV and SST interneurons)",
        "scope_population": "PV and SST interneurons",
        "value_source_sentence": "Two major types of inhibitory neurons are impaired in generation of electrical signals by a DS mutation, whereas excitatory neurons are unaffected.",
        "experimental_conditions": "heterozygous vs wild-type"
      }
    ],
    "comparison_id": "nav1.1-pv-interneuron-dysfunction-across-diseases",
    "comparison_name": "Nav1.1/PV interneuron dysfunction across disease models",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Nav1.1/PV interneuron dysfunction is a shared mechanism across Dravet syndrome epilepsy and Alzheimer's disease, suggesting PV cell excitability as a therapeutic convergence point",
    "homogeneity_check": {
      "caveats": [
        "Paper C includes SST interneurons alongside PV cells",
        "Different brain regions examined across studies",
        "Disease models are different (Dravet vs Alzheimer's) making direct comparison of effect sizes inappropriate",
        "Measurements are qualitative (presence/absence of impairment) rather than quantitative"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "false",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_11_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-11",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-11",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-4cb1cf98f0c1",
    "paper:paper-855d0bdbad3b",
    "paper:paper-fd8f15e7c2e1"
  ],
  "section_title": "Species Translation, Human Data, and Disease Models",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}