Version history

{
  "kind": "infographic",
  "prompt": "Transcriptomic methods resolve substantially more SST subtypes (11 supertypes) than morphological/electrophysiological analysis (3 groups), highlighting the modality-dependent nature of cell type number. Not all transcriptomic supertypes are morphologically distinguishable.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 59,
        "doi": "10.3389/fncir.2010.00012",
        "value": "3",
        "method": "morphological and electrophysiological cluster analysis",
        "metric": "Number of SST subtypes",
        "cite_key": "McGarry2010",
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "GFP-positive neurons characterized by whole-cell recording and reconstruction",
        "scope_region": "mouse somatosensory cortex",
        "study_system": "mouse somatosensory cortex (GIN line)",
        "taxonomic_level": "morphological subtype",
        "scope_population": "somatostatin-positive interneurons",
        "value_source_sentence": "Unsupervised cluster analysis revealed a group comprised of the well-known Martinotti cells, as well as two other sub-groups of SOM-positive neurons that, to our knowledge, have not yet been described."
      },
      {
        "n": 1300000,
        "doi": "10.1016/j.cell.2021.04.021",
        "value": "11",
        "method": "scRNA-seq transcriptomic clustering",
        "metric": "Number of SST supertypes",
        "cite_key": "Yao2021",
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "total cells profiled",
        "scope_region": "entire mouse isocortex",
        "study_system": "mouse isocortex",
        "taxonomic_level": "transcriptomic supertype",
        "scope_population": "Sst subclass GABAergic neurons",
        "value_source_sentence": "In the MGE neighborhood, the Sst Chodl subclass remains as one group (representing long-range projecting Sst cells); the Sst and Pvalb subclasses are divided into 11 and 3 supertypes, respectively (Fig."
      }
    ],
    "comparison_id": "fig_sec2_sst_subtypes",
    "comparison_name": "Number of SST subtypes identified by different classification methods",
    "comparison_type": "cross-method resolution",
    "what_it_reveals": "Transcriptomic methods resolve substantially more SST subtypes (11 supertypes) than morphological/electrophysiological analysis (3 groups), highlighting the modality-dependent nature of cell type number. Not all transcriptomic supertypes are morphologically distinguishable.",
    "homogeneity_check": "Different methods, scales, and scope. Morphological study: n=59 from one cortical area. Transcriptomic study: ~1.3M cells pan-cortex. The taxonomic_level differs: morphological subtypes vs transcriptomic supertypes. Numbers are not directly comparable but the discrepancy illustrates the method-dependence of type counts.",
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  "section_title": "Molecular and Transcriptomic Classification",
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