Striatal Dopamine Signal Properties Across Subregions During Learning

{
  "title": "Striatal Dopamine Signal Properties Across Subregions During Learning",
  "papers": [
    {
      "doi": "10.1016/j.cub.2024.05.069",
      "value": "Early emergence of conditioned DA signal",
      "region": "NAc core",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "predictive cues preferentially recruited dopamine release in NAc core, starting early in training"
    },
    {
      "doi": "10.1016/j.cub.2024.05.069",
      "value": "VTA-evoked DA release present but no conditioned signal preference",
      "region": "NAc shell",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "While VTA stimulation evoked robust dopamine release in NAc core, shell, and DMS"
    },
    {
      "doi": "10.1016/j.cub.2024.05.069",
      "value": "Late emergence of conditioned DA signal; negative prediction error signals present",
      "region": "DMS",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "predictive cues preferentially recruited dopamine release in NAc core, starting early in training, and DMS, late in training. Negative prediction error signals, reflecting a violation in the expectation of dopamine neuron activation, only emerged in the NAc core and DMS."
    },
    {
      "doi": "10.1016/j.cub.2024.05.069",
      "value": "No conditioned DA signal despite robust direct SNC-evoked release",
      "region": "DLS",
      "text_access": "fulltext",
      "study_system": "rat",
      "value_source_sentence": "Despite development of vigorous movement late in training, conditioned dopamine signals did not emerge in the DLS, even during Pavlovian conditioning with SNC dopamine neuron activation, which elicited robust DLS dopamine release."
    }
  ],
  "x_axis": "Striatal subregion",
  "y_axis": "Conditioned dopamine signal characteristics",
  "n_analyzed": "Not specified in abstract",
  "description": "Comparison of conditioned dopamine response emergence across NAc core, NAc shell, DMS, and DLS during Pavlovian learning, showing spatial heterogeneity",
  "figure_type": "grouped_comparison",
  "n_definition": "Number of rats per group",
  "scope_region": "Dorsal and ventral striatal subregions",
  "comparison_id": "striatal_dopamine_dynamics_by_region",
  "taxonomic_level": "regional (NAc core, NAc shell, DMS, DLS)",
  "scope_population": "Dopamine signals measured via fluorescent biosensor (dLight-type)",
  "homogeneity_check": "All data from same study, same species (rat), same sensor, same behavioral paradigm. High internal comparability. Caveat: single lab, optogenetic rather than natural reward conditioning."
}

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]

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