Version history

{
  "kind": "infographic",
  "prompt": "O-LM and bistratified cells, despite both being SST+, show opposite modulation during sharp-wave ripples and distinct theta phase preferences. This demonstrates that treating SST interneurons as a monolithic class obscures functionally critical differences.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1126/science.1149381",
        "value": "O-LM: suppressed during SWRs; Bistratified: strongly active during SWRs",
        "method": "juxtacellular recording in vivo",
        "metric": "SWR activity modulation",
        "cite_key": "Klausberger2008",
        "condition": "anesthetized and awake",
        "study_system": "rat",
        "value_source_sentence": "Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations."
      },
      {
        "doi": "10.1016/j.neuron.2014.04.007",
        "value": "O-LM: active during sleep/immobility; Bistratified: active during movement",
        "method": "juxtacellular recording in vivo",
        "metric": "Behavioral state dependence",
        "cite_key": "Katona2014",
        "condition": "freely moving",
        "study_system": "rat",
        "value_source_sentence": "Sleep and movement differentiates actions of two types of somatostatin-expressing GABAergic interneurons in the hippocampus."
      },
      {
        "doi": "10.1098/rstb.2012.0518",
        "value": "Dendritic inhibition (SST): decreases during ripples; Perisomatic inhibition (PV): increases",
        "method": "in vivo recording",
        "metric": "Inhibition redistribution during SWR",
        "cite_key": "Somogyi2014",
        "condition": "theta to SWR transition",
        "study_system": "rat",
        "value_source_sentence": "Temporal redistribution of inhibition over neuronal subcellular domains underlies state-dependent rhythmic change of excitability in the hippocampus."
      },
      {
        "doi": "10.1523/jneurosci.1397-09.2009",
        "value": "Dendrite-targeting: fire at theta trough; Basket cells: fire at theta peak",
        "method": "juxtacellular recording in vivo",
        "metric": "Theta phase preference",
        "cite_key": "Hartwich2009",
        "condition": "theta oscillations",
        "study_system": "rat",
        "value_source_sentence": "Distinct Firing Patterns of Identified Basket and Dendrite-Targeting Interneurons in the Hippocampus during Theta and Sharp Wave/Ripple Oscillations."
      }
    ],
    "comparison_id": "olm-vs-bistratified-oscillation-coupling",
    "comparison_name": "O-LM vs Bistratified Cell Activity During Hippocampal Network Oscillations",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "O-LM and bistratified cells, despite both being SST+, show opposite modulation during sharp-wave ripples and distinct theta phase preferences. This demonstrates that treating SST interneurons as a monolithic class obscures functionally critical differences.",
    "homogeneity_check": {
      "caveats": "All studies in rat CA1 with juxtacellular recording, but some in anesthetized vs freely moving preparations. Behavioral state is a key variable that affects all measurements.",
      "comparable": true,
      "n_definition": "individual identified neurons",
      "scope_region": "CA1",
      "taxonomic_level": "cell-type specific",
      "scope_population": "identified interneurons"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_09_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_09_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-09",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-09",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-12b8963c5eea",
    "paper:paper-2c384933256d",
    "paper:paper-4b96bf417ed1",
    "paper:paper-f5e82131eb03"
  ],
  "section_title": "Hippocampal SST Interneurons",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_09_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}