5-HT receptor subtypes: opposing actions on neural excitability

{
  "title": "5-HT receptor subtypes: opposing actions on neural excitability",
  "papers": [
    {
      "doi": "10.3390/ijms26157253",
      "value": "5-HT1A inhibitory",
      "n_definition": "recordings",
      "scope_region": "cortex/hippocampus",
      "scope_population": "neurons",
      "value_source_sentence": "The serotonergic system, originating in the raphe nuclei, differentially modulates the dorsal and ventral hippocampus, which are implicated in cognition and emotion, respectively. Emerging evidence from rodent models (e.g., neonatal ventral hippocampal lesion, pharmacological NMDA receptor antagonis"
    },
    {
      "doi": "10.3390/ijms25010241",
      "value": "5-HT2A excitatory",
      "n_definition": "recordings",
      "scope_region": "cortex/hippocampus",
      "scope_population": "neurons",
      "value_source_sentence": "Psychedelics belong to the oldest psychoactive drugs. They arouse recent interest due to their therapeutic applications in the treatment of major depressive disorder, substance use disorder, end-of-life anxiety,= and anxiety symptoms, and obsessive-compulsive disorder. In this review, the current st"
    },
    {
      "doi": "10.3389/fnins.2024.1420601",
      "value": "5-HT2A excitatory",
      "n_definition": "recordings",
      "scope_region": "cortex/hippocampus",
      "scope_population": "neurons",
      "value_source_sentence": "Alzheimer's disease (AD) stands as a formidable neurodegenerative ailment and a prominent contributor to dementia. The scarcity of available therapies for AD accentuates the exigency for innovative treatment modalities. Psilocybin, a psychoactive alkaloid intrinsic to hallucinogenic mushrooms, has g"
    },
    {
      "doi": "10.1038/s41467-024-45734-w",
      "value": "5-HT2A excitatory",
      "n_definition": "recordings",
      "scope_region": "cortex/hippocampus",
      "scope_population": "neurons",
      "value_source_sentence": "Serotonin (5-HT) imbalances in the developing prefrontal cortex (PFC) are linked to long-term behavioral deficits. However, the synaptic mechanisms underlying 5-HT-mediated PFC development are unknown. We found that chemogenetic suppression and enhancement of 5-HT release in the PFC during the first"
    }
  ],
  "figure_id": "fig_sec6_receptor_opposing",
  "n_analyzed": null,
  "description": "Comparison of excitatory (5-HT2A) vs inhibitory (5-HT1A) serotonin receptor effects on pyramidal neuron excitability across studies.",
  "comparison_type": "receptor subtype comparison",
  "taxonomic_level": "receptor subtype",
  "homogeneity_check": {
    "caveats": [
      "Different brain regions across studies",
      "Different cell types targeted",
      "In vitro vs in vivo preparations",
      "Different agonist/antagonist concentrations"
    ],
    "comparable": false
  }
}

[
  "paper:paper-614806ab1c7b",
  "paper:paper-923af613a4a0",
  "paper:paper-9469f226e9df",
  "paper:paper-c393e246f0df"
]

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