PV Interneuron Roles in Fear Circuitry Across Brain Regions

PV interneurons play distinct but complementary roles in fear circuits across prefrontal-amygdala regions: phasic PV suppression in dmPFC drives fear expression, PV-mediated feed-forward inhibition in IL promotes fear relapse, and PV-driven oscillations in BLA bidirectionally control fear memory retrieval. This demonstrates region-specific PV functions within a unified fear circuit.

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1038/nature12755",
      "value": "phasic PV inhibition drives fear expression via disinhibition + theta reset",
      "method": "single-unit recording + optogenetics in behaving mice",
      "metric": "PV role in dmPFC during fear expression",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "abstract_only",
      "n_definition": "recorded neurons",
      "scope_region": "dorsomedial prefrontal cortex",
      "study_system": "mouse, dmPFC, single-unit + optogenetics",
      "taxonomic_level": "PV+ interneurons",
      "scope_population": "PV+ interneurons",
      "value_source_sentence": "fear expression is causally related to the phasic inhibition of prefrontal parvalbumin interneurons (PVINs)",
      "experimental_conditions": "fear conditioning + cue presentation"
    },
    {
      "n": 0,
      "doi": "10.1038/s41593-018-0073-9",
      "value": "vHPC recruits PV cells for feed-forward inhibition promoting fear relapse",
      "method": "whole-cell recording ex vivo + pharmacogenetics in vivo",
      "metric": "PV role in IL cortex during fear relapse",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "recorded neurons",
      "scope_region": "infralimbic prefrontal cortex",
      "study_system": "rat, IL cortex, optogenetics + pharmacogenetics",
      "taxonomic_level": "PV+ interneurons",
      "scope_population": "PV+ interneurons",
      "value_source_sentence": "Selectively silencing parvalbumin-expressing, but not somatostatin-expressing, interneurons in the IL eliminated vHPC-mediated inhibition",
      "experimental_conditions": "extinction + renewal context"
    },
    {
      "n": 0,
      "doi": "10.1038/s41467-020-18199-w",
      "value": "PV-driven 4Hz oscillations support post-extinction fear retrieval",
      "method": "optogenetic PV stimulation + behavior",
      "metric": "PV role in BLA during fear memory retrieval",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "animals per group",
      "scope_region": "basolateral amygdala",
      "study_system": "mouse, BLA + mPFC, optogenetics",
      "taxonomic_level": "PV+ interneurons",
      "scope_population": "PV+ interneurons",
      "value_source_sentence": "exogenously induced 4 Hz and 8 Hz oscillatory activity in the BLA exerts bi-directional control over conditioned freezing behavior",
      "experimental_conditions": "fear conditioning + extinction + retrieval"
    }
  ],
  "comparison_id": "pv-role-in-fear-circuits-across-regions",
  "comparison_name": "PV Interneuron Roles in Fear Circuitry Across Brain Regions",
  "comparison_type": "cross-region comparison",
  "what_it_reveals": "PV interneurons play distinct but complementary roles in fear circuits across prefrontal-amygdala regions: phasic PV suppression in dmPFC drives fear expression, PV-mediated feed-forward inhibition in IL promotes fear relapse, and PV-driven oscillations in BLA bidirectionally control fear memory retrieval. This demonstrates region-specific PV functions within a unified fear circuit.",
  "homogeneity_check": {
    "caveats": [
      "Different species (mouse vs rat) for dmPFC vs IL studies",
      "Different behavioral paradigms and phases of fear learning",
      "PV inhibition in dmPFC vs PV recruitment in IL represent opposite directions of PV engagement"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "circuit diagram"
}

[
  "paper:paper-14612dc2f89b",
  "paper:paper-76b9ba0db913",
  "paper:paper-dc070781ea08"
]

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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
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