{
"papers": [
{
"n": null,
"doi": "10.7150/thno.89592",
"value": "decreased by 80%",
"region": "thalamus",
"study_system": "mouse",
"value_source_sentence": "The burst suppression ratio (BSR) after Purkinje cell activation by photostimulation was decreased during 13 minutes of the observation period after the stimulation, in particular, it was significantly decreased by 80% during the first minute stimulation when compared to those in the mCherry controls (Figure 7 G)."
},
{
"n": null,
"doi": "10.1097/00000542-200202000-00036",
"value": "60%",
"region": "thalamus",
"study_system": "rat",
"value_source_sentence": ", 40–60% after volatile anesthetics), 8,9and it remains poorly understood."
},
{
"n": 2,
"doi": "10.1038/s41467-017-01004-6",
"value": "p = 0.000014",
"region": "thalamus",
"study_system": "human",
"value_source_sentence": "1d ; administration 3 h after lights-on (Zeitgeber (ZT) 3, 10 AM; Latency to sleep: saline 22 ± 4 (SEM), CNO 534 ± 54 min, paired t -test, p = 0.000014, n = 9, see group data Fig."
},
{
"n": null,
"doi": "10.7150/thno.89592",
"value": "decreased by 80%",
"region": "cerebellum",
"study_system": "mouse",
"value_source_sentence": "The burst suppression ratio (BSR) after Purkinje cell activation by photostimulation was decreased during 13 minutes of the observation period after the stimulation, in particular, it was significantly decreased by 80% during the first minute stimulation when compared to those in the mCherry controls (Figure 7 G)."
},
{
"n": null,
"doi": "10.1126/sciadv.abk1378",
"value": "63% enhancement",
"region": "cerebellum",
"study_system": "rat",
"value_source_sentence": "Blue stimulation caused a 63% enhancement of V1 astrocyte locomotion-induced Ca 2+ elevations with no effect on simultaneous cerebellar astroglia Ca 2+ responses (fig."
},
{
"n": null,
"doi": "10.7554/elife.76912",
"value": "110% increase",
"region": "cerebellum",
"study_system": "mouse",
"value_source_sentence": "Puff application of selective Drd1 agonist SKF81297 increased the firing rate of tdT+ UBCs over a period of 10 min ( Figure 2C–D and Figure 1—figure supplement 1A ) (2.48 Hz increase, 110% increase from baseline, n = 13 cells, paired Wilcoxon signed rank test, p=0.02)."
},
{
"n": 6,
"doi": "10.1101/2024.06.18.599619",
"value": "4.6±0.4 s",
"region": "cortex",
"study_system": "mouse",
"value_source_sentence": "Additionally, our ability to dissociate sympathetic (−4.6±0.4 s relative to RORR), cortical (-2.8±0.8 s), subcortical (−0.3±1.0 s), and likely spinal activation ( i.e ."
},
{
"n": 9,
"doi": "10.1038/s41467-018-07566-3",
"value": "71% decrease",
"region": "cortex",
"study_system": "mouse",
"value_source_sentence": "We found that the amount of NE was significantly decreased in the LC, olfactory bulb and prefrontal cortex in mice injected bilaterally with AAV-DJ sgDbh (71% decrease in LC; p = 0.002, 69% decrease in OB; p = 0.0048, 50% decrease in PFC; p = 0.036) compared to mice injected with AAV-DJ sgControl (Fig."
},
{
"n": 12,
"doi": "10.1097/aln.0000000000005659",
"value": "150.1 ± 25.3 s",
"region": "cortex",
"study_system": "mouse",
"value_source_sentence": "Caspase 3; mean ± SD, 150.1 ± 25.3 s vs."
},
{
"n": null,
"doi": "10.1038/s41592-023-01959-z",
"value": "23 ± 5 ms",
"region": "hippocampus",
"study_system": "mouse",
"value_source_sentence": "Using a piezo-controlled system for rapid solution switching between 0 and 5 μM NE in less than 1 ms 13 , we found that nLightG exhibited very rapid activation and deactivation kinetics (τ on = 23 ± 5 ms and τ off = 194 ± 42 ms; mean ± SD, 6 patches, Fig."
},
{
"n": null,
"doi": "10.1111/cns.70360",
"value": "significantly higher",
"region": "hippocampus",
"study_system": "mouse",
"value_source_sentence": "In contrast, the discharge frequency in the SNI + M3 + CNO group was significantly higher relative to both the SNI and SNI + M3 + NS groups (Figure 5E,F )."
},
{
"n": null,
"doi": "10.1093/cercor/bhaa159",
"value": "robust effect",
"region": "hippocampus",
"study_system": "mouse",
"value_source_sentence": "Within the hippocampus, the major effects of NA on cellular excitability are mediated via β-ARs where the most robust effect is inhibition of the slow afterhyperpolarization (sAHP) ( Madison and Nicoll 1982 ; Haas and Konnerth 1983 ; Sah and Isaacson 1995 ), which has been correlated with increased spiking and enhanced learning ( Oh et al."
},
{
"n": 690,
"doi": "10.1101/lm.047282.117",
"value": "r = 0.14",
"region": "amygdala",
"study_system": "rat",
"value_source_sentence": "We observed that the magnitude of the effects of arousal on encoding and consolidation, i.e., immediate emotional enhancement of memory (iEEM) and delayed emotional enhancement of memories (dEEM), correlated only weakly with each other across participants ( r = 0.14) ( Schümann et al."
},
{
"n": null,
"doi": "10.3390/ijms241311193",
"value": "p = 0.007",
"region": "amygdala",
"study_system": "rat",
"value_source_sentence": "Both sexes exhibited significantly increased anxiety-like behavior, exhibited by making fewer transitions to the open arms on the EPM (one-way ANOVA, F 3, 127 = 6.052, p = 0.007; Tukey post hoc test; female SPS vs."
},
{
"n": 2,
"doi": "10.1186/s12974-025-03527-y",
"value": "significantly greater",
"region": "amygdala",
"study_system": "mouse",
"value_source_sentence": "Specifically, the GiSL group exhibited significantly greater novel arm entries than the CDL group ( P < 0.01) and CSL mice ( P < 0.05), while novel arm dwell time was also improved ( P < 0.05 vs."
}
],
"x_axis": "Brain region",
"y_axis": "Effect magnitude (fold change or % change in firing/synaptic response)",
"n_analyzed": "varies by study — see individual entries",
"description": "Comparison of NE/LC stimulation effects on neural firing or synaptic responses across major target regions",
"figure_type": "grouped_bar_or_forest_plot",
"n_definition": "number of neurons or recordings per study",
"scope_region": "multiple brain regions (cortex, hippocampus, amygdala, thalamus, cerebellum)",
"comparison_type": "NE modulation effects across brain regions",
"taxonomic_level": "N/A",
"scope_population": "principal neurons in each region",
"homogeneity_check": {
"caveats": [
"Different brain regions have different baseline firing rates and NE receptor distributions",
"Studies use different methods (iontophoresis vs LC stimulation vs bath application)",
"Some studies measure firing rate changes, others measure synaptic responses (LTP/LTD)",
"Concentration-dependent effects make cross-study comparison approximate",
"Species differences (rat vs mouse) affect comparability"
],
"comparable": false
}
}