Thalamocortical Feedforward Inhibition Strength Across Brain Regions

Across brain regions and species, thalamocortical feedforward inhibition consistently recruits PV/FS interneurons preferentially over other interneuron types. The strength and timing properties vary by region (more flexible in PFC vs sensory cortex) but the basic motif is conserved from barrel cortex to PFC to motor cortex.

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1523/jneurosci.4727-04.2006",
      "value": "10x",
      "method": "paired intracellular recordings",
      "metric": "FS inhibition potency relative to excitatory connections",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "abstract_only",
      "n_definition": "paired recordings in barrel cortex L4",
      "scope_region": "barrel cortex layer IV",
      "study_system": "rat barrel cortex layer IV",
      "taxonomic_level": "FS/PV basket cells",
      "scope_population": "FS interneurons to spiny stellate cells",
      "value_source_sentence": "Inhibition mediated by fast-spiking (FS) interneurons is 10 times more powerful.",
      "experimental_conditions": "in vitro thalamocortical slice, paired intracellular recordings"
    },
    {
      "n": 0,
      "doi": "10.1523/JNEUROSCI.4565-14.2015",
      "value": "limits temporal integration window with greater flexibility than sensory cortex",
      "method": "optogenetics + patch-clamp",
      "metric": "PV-mediated feedforward inhibition temporal constraint",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "paired recordings in dACC L3",
      "scope_region": "dorsal anterior cingulate cortex layer 3",
      "study_system": "mouse anterior cingulate cortex",
      "taxonomic_level": "PV interneurons",
      "scope_population": "PV interneurons mediating MD thalamic feedforward inhibition",
      "value_source_sentence": "This feedforward inhibition in the dACC limits the time window during which pyramidal neurons integrate excitatory synaptic inputs and fire action potentials, but in a manner that allows for greater flexibility than in sensory cortex.",
      "experimental_conditions": "in vitro optogenetic stimulation of MD thalamic inputs"
    },
    {
      "n": 0,
      "doi": "10.1016/j.neuron.2009.12.025",
      "value": "robust FS responses, weak SOM responses",
      "method": "optogenetics + electrophysiology",
      "metric": "TC input relative strength to FS vs SOM interneurons",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "optogenetic activation + patch-clamp recordings",
      "scope_region": "somatosensory cortex",
      "study_system": "mouse thalamocortical circuits",
      "taxonomic_level": "FS vs SOM interneurons",
      "scope_population": "FS and SOM interneurons receiving TC input",
      "value_source_sentence": "Laser stimulation of ChR2-expressing thalamocortical axons/terminals evoked robust synaptic responses in cortical excitatory cells and fast-spiking (FS) inhibitory interneurons, but only weak responses in somatostatin-containing interneurons.",
      "experimental_conditions": "in vitro, ChR2-expressing TC or CT axons"
    },
    {
      "n": 0,
      "doi": "10.1016/j.celrep.2022.110803",
      "value": "PV activity precedes pyramidal cell firing during movement",
      "method": "in vivo electrophysiology",
      "metric": "PV recruitment timing relative to pyramidal cells",
      "n_analyzed": "",
      "ci_or_error": "",
      "text_access": "fulltext",
      "n_definition": "in vivo single unit recordings",
      "scope_region": "motor cortex",
      "study_system": "non-human primate motor cortex",
      "taxonomic_level": "PV interneurons",
      "scope_population": "PV interneurons receiving cerebellar thalamic input",
      "value_source_sentence": "We also find that the movement-related activity of PV interneurons precedes firing of pyramidal cells.",
      "experimental_conditions": "in vivo during task performance, cerebellar-thalamocortical pathway"
    }
  ],
  "comparison_id": "feedforward-inhibition-strength-across-pathways",
  "comparison_name": "Thalamocortical Feedforward Inhibition Strength Across Brain Regions",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "Across brain regions and species, thalamocortical feedforward inhibition consistently recruits PV/FS interneurons preferentially over other interneuron types. The strength and timing properties vary by region (more flexible in PFC vs sensory cortex) but the basic motif is conserved from barrel cortex to PFC to motor cortex.",
  "homogeneity_check": {
    "caveats": [
      "Different brain regions compared (barrel cortex, dACC, somatosensory cortex, motor cortex)",
      "Different species (rat, mouse, non-human primate)",
      "Different methods (paired recordings vs optogenetics vs in vivo)",
      "Metric definitions not directly comparable across studies"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-046e316a15e6",
  "paper:paper-2f3c85a13dfa",
  "paper:paper-86169cad4277",
  "paper:paper-fa3340a4bd01"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}