astrocyte_GPCR_Ca2+_manipulation_alters_cortical_slow_oscillation_power

{
  "papers": [
    {
      "doi": "10.1073/pnas.1520759113",
      "year": 2016,
      "value": "switched to slow-oscillation-dominated state",
      "metric": "local cortical circuit state after astrocyte optogenetic activation",
      "finding": "Optogenetic activation of astrocytes switches cortical circuit to slow-oscillation-dominated state",
      "journal": "PNAS",
      "direction": "astrocyte activation → switched circuit to slow-oscillation state (↑ SWA)",
      "first_author": "Poskanzer",
      "manipulation": "Astrocyte optogenetic activation (ChR2) in mouse visual cortex, in vivo two-photon",
      "source_location": "abstract",
      "source_sentence": "Further, we show that optogenetic activation of astrocytes switches the local neuronal circuit to this slow-oscillation state.",
      "value_source_sentence": "Further, we show that optogenetic activation of astrocytes switches the local neuronal circuit to this slow-oscillation state."
    },
    {
      "doi": "10.7554/elife.63329",
      "year": 2021,
      "value": "Gi-signaling → increased NREM sleep depth; Gq-signaling → increased NREM sleep duration (dissociable)",
      "metric": "NREM sleep features (depth / slow-wave-activity and duration) under astrocytic Gi- vs Gq-GPCR activation",
      "finding": "Astrocytic Gi- and Gq-coupled GPCR signaling separately control NREM sleep depth and duration",
      "journal": "eLife",
      "direction": "Gi activation → ↑ NREM depth (SWA); Gq activation → ↑ NREM duration",
      "first_author": "Vaidyanathan",
      "manipulation": "Astrocyte chemogenetic Gi- vs Gq-DREADD activation, somatosensory cortex, in vivo",
      "source_location": "abstract",
      "source_sentence": "We find that astrocytic Gi- and Gq-coupled GPCR signaling separately control NREM sleep depth and duration, respectively, and that astrocytic signaling causes differential changes in local and remote cortex.",
      "value_source_sentence": "We find that astrocytic Gi- and Gq-coupled GPCR signaling separately control NREM sleep depth and duration, respectively, and that astrocytic signaling causes differential changes in local and remote cortex."
    },
    {
      "doi": "10.1038/s41467-020-17062-2",
      "year": 2020,
      "value": "slow wave sleep impaired; increased microarousals, abnormal brain rhythms, increased state transitions and spindles",
      "metric": "slow-wave-sleep integrity (microarousal count, brain-rhythm pattern, state-transition frequency, sleep spindle count) in IP3R2-KO mice",
      "finding": "IP3R2 ablation impairs slow-wave sleep, increases microarousals, produces abnormal brain rhythms",
      "journal": "Nature Communications",
      "direction": "loss of astrocyte Ca2+ signaling → disrupted slow-wave sleep (↓ SWA integrity)",
      "first_author": "Bojarskaite",
      "manipulation": "IP3R2 global genetic knockout (ablation of astrocyte Gq-Ca2+ pathway)",
      "source_location": "abstract",
      "source_sentence": "Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles.",
      "value_source_sentence": "Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles."
    }
  ],
  "concordance": "All three papers agree that astrocyte Ca2+/GPCR signaling causally shapes cortical slow oscillations and NREM sleep depth.",
  "description": "Gain- and loss-of-function manipulations of astrocyte Ca2+/GPCR signaling produce bidirectional effects on cortical slow oscillations and NREM sleep depth. Astrocyte optogenetic or Gi-DREADD activation increases slow-oscillation/SWA power; IP3R2 global knockout disrupts slow-wave sleep integrity.",
  "disagreements": "Direction differs by manipulation axis — activation (Poskanzer ChR2; Vaidyanathan Gi-DREADD) increases SWA; genetic ablation (Bojarskaite IP3R2-KO) disrupts slow-wave sleep. Not a contradiction; reflects bidirectional control.",
  "comparison_name": "astrocyte_GPCR_Ca2+_manipulation_alters_cortical_slow_oscillation_power"
}

[
  "paper:paper-0441c28ad125",
  "paper:paper-9a1be146dacd",
  "paper:paper-da0aeffaf2b1"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "1a55da0634a3bc04e5688792ed12141ce271d28e",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes"
}