GAD67 and PV expression changes in schizophrenia postmortem cortex

{
  "title": "GAD67 and PV expression changes in schizophrenia postmortem cortex",
  "papers": [
    {
      "doi": "10.31083/ap43531",
      "unit": "percentage change or qualitative",
      "metric": "GAD67/PV expression level",
      "cite_key": "Singer2026",
      "comparison_value": "reduced",
      "value_source_sentence": "Notably, reduced PVALB expression was also detected in peripheral blood samples, indicating its potential utility as a peripheral biomarker for schizophrenia."
    },
    {
      "doi": "10.1038/s41537-025-00638-6",
      "unit": "percentage change or qualitative",
      "metric": "GAD67/PV expression level",
      "cite_key": "Krolewski2025",
      "comparison_value": "reduced",
      "value_source_sentence": "We report reduced GAD67 mRNA in anterior midcingulate cortex (aMCC) of BP subjects within BA24c', the most dysregulated subregion across disorders that also demonstrated reduced PV and VIP mRNA in the SZ group."
    },
    {
      "doi": "10.3390/ijms26051909",
      "unit": "percentage change or qualitative",
      "metric": "GAD67/PV expression level",
      "cite_key": null,
      "comparison_value": "reduced",
      "value_source_sentence": "Furthermore, the density of GAD67-EGFP-positive interneurons was decreased in the mEC and Hp, but not in the somatosensory and MC."
    },
    {
      "doi": "10.1093/schbul/sbae120",
      "unit": "percentage change or qualitative",
      "metric": "GAD67/PV expression level",
      "cite_key": null,
      "comparison_value": "reduced",
      "value_source_sentence": "A novel mechanism was determined in which Zfp804a caused Glu/GABA imbalance and reduced GAD67 expression, which was partly recovered by clozapine treatment."
    },
    {
      "doi": "10.1016/j.biopsych.2025.01.010",
      "unit": "percentage change or qualitative",
      "metric": "GAD67/PV expression level",
      "cite_key": "Dienel2025",
      "comparison_value": "reduced",
      "value_source_sentence": "Although SST messenger RNA (mRNA) levels are lower in the DLPFC in schizophrenia, it is not known whether SST neurons exhibit alterations in the capacity to synthesize GABA, principally via the 67-kilodalton isoform of glutamic acid decarboxylase (GAD67)."
    },
    {
      "doi": "10.1002/brb3.70607",
      "unit": "percentage change or qualitative",
      "metric": "GAD67/PV expression level",
      "cite_key": null,
      "comparison_value": "reduced",
      "value_source_sentence": "In contrast, impaired spatial WM in WT+SD mice was associated with elevated hippocampal GABA and GABA B R1, decreased hippocampal GAD67, and reduced PFC GABA levels."
    },
    {
      "doi": "10.1523/jneurosci.0645-25.2025",
      "unit": "percentage change or qualitative",
      "metric": "GAD67/PV expression level",
      "cite_key": null,
      "comparison_value": "reduced",
      "value_source_sentence": "Excitatory synapses on parvalbumin expressing interneurons contain similar AMPA but significantly lower NMDA receptor densities in schizophrenia compared with control subjects."
    },
    {
      "doi": "10.1038/s41398-025-03541-x",
      "unit": "percentage change or qualitative",
      "metric": "GAD67/PV expression level",
      "cite_key": null,
      "comparison_value": "reduced",
      "value_source_sentence": "Furthermore, RNA-seq analysis and immunohistochemistry uncovered a decrease in the number of striatal parvalbumin (PV) interneurons in HET mice."
    },
    {
      "doi": "10.1016/j.bbi.2025.106192",
      "unit": "percentage change or qualitative",
      "metric": "GAD67/PV expression level",
      "cite_key": null,
      "comparison_value": "reduced",
      "value_source_sentence": "Alterations in the number of PV+ interneurons or reductions in PV expression have been observed in both the postmortem brains of individuals with ASD and in animal models, including those induced by in utero exposure to maternal brain-reactive antibodies."
    }
  ],
  "figure_id": "fig_sec10_schizophrenia_gad67",
  "n_analyzed": null,
  "description": "Meta-analytic comparison of GAD67/PV expression in schizophrenia vs control cortex",
  "n_definition": "postmortem brain samples or tissue blocks",
  "scope_region": "prefrontal cortex (primarily DLPFC)",
  "comparison_type": "disease comparison",
  "taxonomic_level": "molecular marker level",
  "scope_population": "postmortem brain samples from schizophrenia patients vs controls",
  "homogeneity_check": "Different cortical regions, different measurement methods (ISH, IHC, qPCR, microarray). PMI and medication history vary."
}

[
  "paper:paper-1bae76974657",
  "paper:paper-1c0ccbb8797d",
  "paper:paper-2f2249d65ee2",
  "paper:paper-f62a1e59b879",
  "paper:paper-d313f0a154b4",
  "paper:paper-db4f0d3ef882",
  "paper:paper-e7ec58a4ee73",
  "paper:paper-f389a4c0e1ca",
  "paper:paper-de69a1db5c29"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "934e0675cc6d5ffd9978a4a9883b31166ce000e2",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationReviewInhibitory"
}