L1 interneuron types: mouse vs human comparison

Human L1 contains all four mouse L1 interneuron subclasses plus additional unique types, demonstrating evolutionary expansion of the L1 inhibitory repertoire in humans. This has implications for translating mouse circuit findings to human cortex.

{
  "papers": [
    {
      "n": null,
      "doi": "10.1126/science.adf0805",
      "value": "4",
      "method": "Patch-seq",
      "metric": "Number of L1 transcriptomic subclasses (mouse)",
      "cite_key": "Chartrand2023",
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "Patch-seq recordings from mouse L1",
      "scope_region": "mouse neocortex layer 1",
      "study_system": "mouse neocortex L1",
      "taxonomic_level": "transcriptomic subclass",
      "scope_population": "L1 interneurons",
      "value_source_sentence": "In rodents, a progression of classification schemes for L1 neurons (13–18) has evolved towards a view of 4 canonical types based on molecular markers (19), but the robustness of this scheme, both across modalities and across species, remains unclear"
    },
    {
      "n": null,
      "doi": "10.1126/science.adf0805",
      "value": "4 homologous + additional unique subtypes",
      "method": "Patch-seq",
      "metric": "Number of L1 transcriptomic subclasses (human) including unique types",
      "cite_key": "Chartrand2023",
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "Patch-seq recordings from human neurosurgical tissue",
      "scope_region": "human neocortex layer 1",
      "study_system": "human neocortex L1",
      "taxonomic_level": "transcriptomic subclass",
      "scope_population": "L1 interneurons",
      "value_source_sentence": "Using patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologues, along with unique subtypes and types unmatched in mouse L1."
    }
  ],
  "comparison_id": "fig_sec2_l1_types_species",
  "comparison_name": "L1 interneuron types: mouse vs human comparison",
  "comparison_type": "cross-species comparison",
  "what_it_reveals": "Human L1 contains all four mouse L1 interneuron subclasses plus additional unique types, demonstrating evolutionary expansion of the L1 inhibitory repertoire in humans. This has implications for translating mouse circuit findings to human cortex.",
  "homogeneity_check": "Same study, same methodology (Patch-seq), same layer (L1), comparing across species. Direct comparison is valid though human data comes from neurosurgical tissue (epilepsy patients) which may differ from healthy tissue.",
  "suggested_plot_type": "paired_comparison"
}

[
  "paper:paper-86dac47be132"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "934e0675cc6d5ffd9978a4a9883b31166ce000e2",
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