Version history

{
  "kind": "infographic",
  "prompt": "Compares resting membrane potential, spike threshold, and other voltage parameters across SST subtypes and studies, revealing whether subtype-specific voltage operating ranges exist.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.7554/elife.92915",
        "value": "voltage: 30 mV",
        "method": "whole-cell patch-clamp",
        "metric": "voltage parameter",
        "cite_key": "Shore2024",
        "condition": "in vitro",
        "study_system": "mouse, cortex, in vivo",
        "value_source_sentence": "Heterozygous Kcnt1Y777H expression increases subthreshold KNa currents in NFS GABAergic neuronsPreviously, we showed that homozygous Kcnt1Y777H expression in GABAergic cortical neurons increases the KNa current across subthreshold voltages, an effect that is particularly evident in NFS GABAergic neu"
      },
      {
        "doi": "10.1016/j.isci.2025.112539",
        "value": "voltage: 0.164 mV",
        "method": "whole-cell patch-clamp",
        "metric": "voltage parameter",
        "cite_key": "Feyerabend2025",
        "condition": "in vitro",
        "study_system": "cortex",
        "value_source_sentence": "0.164 mV∗s, U = 110) and amplitude (medians 1.849 vs."
      },
      {
        "doi": "10.1073/pnas.2306382121",
        "value": "voltage: 90 mV",
        "method": "whole-cell patch-clamp",
        "metric": "voltage parameter",
        "cite_key": "Chamberland2024",
        "condition": "in vitro",
        "study_system": "mouse, cortex",
        "value_source_sentence": "Each panel includes a response to hyperpolarizing pulse driving Vm between −100 and −90 mV, a response to rheobase current pulse (color), and the maximal firing rate response (gray)."
      },
      {
        "doi": "10.1523/eneuro.0089-23.2023",
        "value": "voltage: 16 mV",
        "method": "whole-cell patch-clamp",
        "metric": "voltage parameter",
        "cite_key": "HernandezVivanco2023",
        "condition": "in vitro",
        "study_system": "mouse, cortex, in vivo",
        "value_source_sentence": "The reversal potential for chloride (ECl) is ∼16 mV in high-chloride solutions and −80 mV in low-chloride solutions based on the Nernst equation, without correction for liquid junction potential."
      }
    ],
    "comparison_id": "sst-voltage-parameters",
    "comparison_name": "Resting Potential and Voltage Parameters of SST Interneurons",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "Compares resting membrane potential, spike threshold, and other voltage parameters across SST subtypes and studies, revealing whether subtype-specific voltage operating ranges exist.",
    "homogeneity_check": {
      "caveats": [
        "Junction potential corrections vary across labs",
        "Different internal solutions shift measured potentials",
        "Recording temperature affects voltage parameters"
      ],
      "comparable": false
    },
    "suggested_plot_type": "forest plot"
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_05_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-05",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-05",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-01908403ed00",
    "paper:paper-07cdd22cd16b",
    "paper:paper-cf171ce288a9",
    "paper:paper-f4bf74d36e26"
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_05_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}