Version history

{
  "kind": "infographic",
  "prompt": "Across in vitro and in vivo preparations, thalamocortical input consistently recruits FS/PV interneurons preferentially and rapidly, with SOM interneurons receiving weaker direct TC drive. This establishes the FS/PV-mediated feedforward inhibition motif as a robust feature of thalamocortical processing, with a clear temporal hierarchy: FS first, then excitatory neurons, then SOM cells.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1523/jneurosci.21-08-02699.2001",
        "value": "~60%",
        "method": "cell-attached + whole-cell recording",
        "metric": "fraction of inhibitory neurons firing on TC stimulation",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "abstract_only",
        "n_definition": "cell-attached recordings in barrel cortex",
        "scope_region": "barrel cortex layers IV-V",
        "study_system": "mouse barrel cortex",
        "taxonomic_level": "broad: inhibitory vs excitatory",
        "scope_population": "all inhibitory and excitatory neurons",
        "value_source_sentence": "Thalamocortical stimulation evoked action potentials in ~60% of inhibitory interneurons but in <5% of excitatory neurons.",
        "experimental_conditions": "in vitro, thalamocortical electrical stimulation"
      },
      {
        "n": 0,
        "doi": "10.1016/j.neuron.2009.12.025",
        "value": "robust to FS, weak to SOM",
        "method": "optogenetics + electrophysiology",
        "metric": "TC input strength to FS vs SOM interneurons",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "optogenetic TC activation + patch-clamp",
        "scope_region": "somatosensory cortex",
        "study_system": "mouse somatosensory cortex",
        "taxonomic_level": "FS vs SOM interneurons",
        "scope_population": "FS and SOM interneurons",
        "value_source_sentence": "Laser stimulation of ChR2-expressing thalamocortical axons/terminals evoked robust synaptic responses in cortical excitatory cells and fast-spiking (FS) inhibitory interneurons, but only weak responses in somatostatin-containing interneurons.",
        "experimental_conditions": "in vitro, ChR2 optogenetic activation of TC axons"
      },
      {
        "n": 0,
        "doi": "10.1016/j.neuron.2019.07.027",
        "value": "FS first, then E and SST; VIP weak",
        "method": "in vivo electrophysiology",
        "metric": "latency of interneuron type recruitment by touch",
        "n_analyzed": "",
        "ci_or_error": "",
        "text_access": "fulltext",
        "n_definition": "in vivo single unit recordings during behavior",
        "scope_region": "barrel cortex",
        "study_system": "mouse barrel cortex",
        "taxonomic_level": "FS, E, SST, VIP",
        "scope_population": "all four main cell types during active touch",
        "value_source_sentence": "Touch excited fast-spiking (FS) interneurons at short latency, followed by activation of excitatory (E) neurons and somatostatin-expressing (SST) interneurons. Touch only weakly modulated vasoactive intestinal polypeptide-expressing (VIP) interneurons.",
        "experimental_conditions": "in vivo during active whisker-dependent object localization"
      }
    ],
    "comparison_id": "interneuron-recruitment-by-thalamocortical-input",
    "comparison_name": "Differential Recruitment of Interneuron Types by Thalamocortical Input",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Across in vitro and in vivo preparations, thalamocortical input consistently recruits FS/PV interneurons preferentially and rapidly, with SOM interneurons receiving weaker direct TC drive. This establishes the FS/PV-mediated feedforward inhibition motif as a robust feature of thalamocortical processing, with a clear temporal hierarchy: FS first, then excitatory neurons, then SOM cells.",
    "homogeneity_check": {
      "caveats": [
        "Mix of in vitro and in vivo preparations",
        "Different interneuron classification granularity across studies",
        "First study uses broad inhibitory/excitatory classification while later studies identify specific subtypes"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "true",
      "taxonomic_level_uniform": "false",
      "scope_population_uniform": "false"
    },
    "suggested_plot_type": "timeline"
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-07",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-046e316a15e6",
    "paper:paper-3eb6456daece",
    "paper:e5dc2921-2ba0-4d4f-a34c-67e2b13a356d"
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}