Details

kind
infographic
prompt
Inhibitory neuron types identified across transcriptomic studies
provider
other
section_id
section_06_evidence
source_url
https://github.com/AllenNeuralDynamics/ComputationReviewInhibitory/blob/934e0675cc6d5ffd9978a4a9883b31166ce000e2/evidence/section_06_evidence.json
target_ref
wiki_page:computationreviewinhibitory-06
review_repo
ComputationReviewInhibitory
section_ref
wiki_page:computationreviewinhibitory-06
source_path
evidence/section_06_evidence.json
section_title
VIP Interneuron Function and Disinhibition
generation_status
complete
review_bundle_ref
analysis_bundle:ab-5fc3c0c0505b
origin_url
https://github.com/AllenNeuralDynamics/ComputationReviewInhibitory/blob/934e0675cc6d5ffd9978a4a9883b31166ce000e2/evidence/section_06_evidence.json
commit_sha
934e0675cc6d5ffd9978a4a9883b31166ce000e2
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationReviewInhibitory
Raw fields (3)
raw_fields
{
  "papers": [
    {
      "n": null,
      "doi": "10.1038/s41586-021-03465-8",
      "value": "1 (from abstract context)",
      "cite_key": "Bakken2021",
      "n_definition": "number of cell types or cells profiled",
      "scope_region": "mouse cortex",
      "scope_population": "GABAergic interneurons",
      "value_source_sentence": "The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals<sup>1</sup>."
    },
    {
      "n": null,
      "doi": "10.1101/2020.03.31.016972",
      "value": "1 (from abstract context)",
      "cite_key": "Bakken2020",
      "n_definition": "number of cell types or cells profiled",
      "scope_region": "mouse cortex",
      "scope_population": "GABAergic interneurons",
      "value_source_sentence": "Abstract The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally conserved across mammals."
    },
    {
      "n": 3,
      "doi": "10.1038/s41467-024-50414-w",
      "value": "3 (from abstract context)",
      "cite_key": "Garma2024",
      "n_definition": "number of cell types or cells profiled",
      "scope_region": "mouse cortex",
      "scope_population": "GABAergic interneurons",
      "value_source_sentence": "Notably, based on key functional genes such as ion channels and synaptic receptors, we found matching known mouse interneuron populations for the most abundant populations, the recently described PTHLH and TAC3 interneurons."
    },
    {
      "n": null,
      "doi": "10.1016/j.celrep.2025.116904",
      "value": "26 (from abstract context)",
      "cite_key": "Li2026b",
      "n_definition": "number of cell types or cells profiled",
      "scope_region": "mouse cortex",
      "scope_population": "GABAergic interneurons",
      "value_source_sentence": "Our spatial transcriptomic atlas resolves 26 Sim1<sup>+</sup> and 29 GABAergic neuron populations from the PVH and surrounding areas."
    },
    {
      "n": null,
      "doi": "10.1371/journal.pbio.2006387",
      "value": "1 (from abstract context)",
      "cite_key": "Harris2018",
      "n_definition": "number of cell types or cells profiled",
      "scope_region": "mouse cortex",
      "scope_population": "GABAergic interneurons",
      "value_source_sentence": "In hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to date."
    },
    {
      "n": null,
      "doi": "10.1038/s41598-024-81140-4",
      "value": "10 (from abstract context)",
      "cite_key": "BenMahmoud2025",
      "n_definition": "number of cell types or cells profiled",
      "scope_region": "mouse cortex",
      "scope_population": "GABAergic interneurons",
      "value_source_sentence": "We provide a thorough description of the maturation process of h-iPSC-Ns over a 10-week in vitro period using conventional whole-cell patch clamp and dynamic clamp techniques, alongside with morphometry and immunocytochemistry."
    }
  ],
  "x_axis": "Study / Method",
  "y_axis": "Number of inhibitory types identified",
  "n_analyzed": "varies",
  "n_definition": "number of cells profiled or types identified",
  "scope_region": "mouse and human cortex",
  "comparison_name": "Inhibitory neuron types identified across transcriptomic studies",
  "comparison_type": "cross_study",
  "taxonomic_level": "transcriptomic types and subtypes",
  "scope_population": "GABAergic interneurons",
  "homogeneity_check": {
    "caveats": [
      "Different clustering methods and resolution parameters",
      "Different brain regions sampled",
      "Different species (mouse vs human)",
      "Definition of \"type\" varies (transcriptomic cluster vs morphological class)",
      "Coverage depth varies (some studies profile thousands, others millions of cells)"
    ],
    "comparable": false
  }
}
source_refs
[
  "paper:paper-16f7339a897e",
  "paper:paper-pm-34616062",
  "paper:paper-6fd28d55ddb8",
  "paper:paper-d07d171dd45c",
  "paper:paper-99ef33b04716",
  "paper:paper-a61009d50e9b"
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "934e0675cc6d5ffd9978a4a9883b31166ce000e2",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationReviewInhibitory"
}

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