astrocyte_Ca2+_signaling_lower_during_sleep_vs_wake

{
  "papers": [
    {
      "doi": "10.1038/s41467-020-17062-2",
      "year": 2020,
      "value": "reduced during sleep relative to wakefulness",
      "metric": "astrocytic Ca2+ signal level across sleep-wake states",
      "system": "awake/sleeping mouse neocortex, two-photon GCaMP6f, freely behaving",
      "finding": "Astrocytic Ca2+ signaling is reduced during sleep compared to wakefulness",
      "journal": "Nature Communications",
      "direction": "reduced in sleep",
      "first_author": "Bojarskaite",
      "source_location": "abstract",
      "source_sentence": "We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness.",
      "value_source_sentence": "We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness."
    },
    {
      "doi": "10.1016/j.cub.2020.08.052",
      "year": 2020,
      "value": "highest in wake, lowest in sleep",
      "metric": "astroglial calcium signal magnitude across vigilance states",
      "system": "freely-behaving mouse (miniature microscope) + head-fixed two-photon, frontal cortex",
      "finding": "Astroglial Ca2+ signals highest in wake, lowest in sleep",
      "journal": "Current Biology",
      "direction": "reduced in sleep",
      "first_author": "Ingiosi",
      "source_location": "abstract",
      "source_sentence": "Using a miniature microscope in freely behaving mice and a two-photon microscope in head-fixed, unanesthetized mice, we show that astroglial calcium signals are highest in wake and lowest in sleep and are most pronounced in astroglial processes.",
      "value_source_sentence": "Using a miniature microscope in freely behaving mice and a two-photon microscope in head-fixed, unanesthetized mice, we show that astroglial calcium signals are highest in wake and lowest in sleep and are most pronounced in astroglial processes."
    },
    {
      "doi": "10.7554/elife.63329",
      "year": 2021,
      "value": "negatively correlated across behavioral states",
      "metric": "correlation between cortical astrocyte Ca2+ event rate and cortical slow-wave activity (SWA, 0.5-4 Hz power)",
      "system": "head-fixed mouse, two-photon GCaMP6f, somatosensory cortex",
      "finding": "Cortical astrocyte Ca2+ event rate and SWA are negatively correlated across behavioral states",
      "journal": "eLife",
      "direction": "reduced in sleep (negatively correlated with SWA)",
      "first_author": "Vaidyanathan",
      "source_location": "fulltext (results)",
      "source_sentence": "Cortical astrocyte Ca 2+ event rate and SWA are negatively correlated across behavioral states.",
      "value_source_sentence": "Cortical astrocyte Ca 2+ event rate and SWA are negatively correlated across behavioral states."
    }
  ],
  "concordance": "concordant — three labs using independent methodologies converge on reduced cortical astrocyte Ca2+ during NREM sleep vs wake",
  "description": "Three independent in vivo two-photon/miniscope studies in mouse neocortex report that cortical astrocyte Ca2+ activity is lower during NREM sleep than during wakefulness. All three converge on a common direction of effect across different Ca2+ indicators (GCaMP6/7), mouse lines, and cortical regions (frontal, somatosensory, visual).",
  "disagreements": "None on direction; quantitative effect sizes vary due to different analysis pipelines (ROA-based event detection vs global event rate vs spatiotemporal AQuA analysis) and cortical regions sampled",
  "comparison_name": "astrocyte_Ca2+_signaling_lower_during_sleep_vs_wake"
}

[
  "paper:paper-0441c28ad125",
  "paper:paper-7f6000297c9c",
  "paper:paper-9a1be146dacd"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "1a55da0634a3bc04e5688792ed12141ce271d28e",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes"
}