Version history

{
  "kind": "infographic",
  "prompt": "D1/D2 receptor co-expression rates across striatal subregions",
  "provider": "other",
  "raw_fields": {
    "title": "D1/D2 receptor co-expression rates across striatal subregions",
    "papers": [
      {
        "doi": "10.1038/srep41432",
        "unit": "% of MSNs",
        "value": 1.9,
        "method": "double BAC transgenic (Drd1a-tdTomato/Drd2-EGFP)",
        "region": "dorsal striatum",
        "species": "mouse",
        "value_source_sentence": "D1/D2 MSNs are uniformly distributed throughout the dorsal striatum (1.9% of MSNs)."
      },
      {
        "doi": "10.1038/srep41432",
        "unit": "% of MSNs",
        "value": 14.6,
        "method": "double BAC transgenic",
        "region": "NAc shell",
        "species": "mouse",
        "value_source_sentence": "In contrast, they are heterogeneously distributed and more numerous in the ventral striatum (14.6% in the shell and 7.3% in the core)."
      },
      {
        "doi": "10.1038/srep41432",
        "unit": "% of MSNs",
        "value": 7.3,
        "method": "double BAC transgenic",
        "region": "NAc core",
        "species": "mouse",
        "value_source_sentence": "In contrast, they are heterogeneously distributed and more numerous in the ventral striatum (14.6% in the shell and 7.3% in the core)."
      }
    ],
    "x_axis": "Striatal subregion",
    "y_axis": "Percentage of MSNs co-expressing D1 and D2",
    "n_analyzed": "not explicitly reported in abstract; double BAC transgenic counting approach",
    "n_definition": "individual MSNs counted in striatal subregions",
    "scope_region": "mouse striatum (dorsal + ventral)",
    "comparison_id": "fig_sec3_d1d2_coexpression",
    "comparison_type": "regional co-expression quantification",
    "taxonomic_level": "cell type (D1+, D2+, D1/D2+ MSNs)",
    "scope_population": "medium spiny neurons (MSNs)",
    "homogeneity_check": "All data from single study using consistent transgenic reporter approach. Subregion comparisons are internally controlled. Limitation: reporter-based detection may under- or over-estimate true receptor co-expression vs. single-cell transcriptomics or protein co-localization."
  },
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  "section_title": "Receptor Pharmacology and Region-Specific Expression",
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